CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013367
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hydroxysteroid dehydrogenase-like protein 2 
Protein Synonyms/Alias
  
Gene Name
 Hsdl2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
24GASRGIGKAIALKAAacetylation[1]
141KACIPFLKKSKVAHIacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Has apparently no steroid dehydrogenase activity (By similarity). 
Sequence Annotation
 DOMAIN 414 521 SCP2.
 NP_BIND 17 23 NADP (By similarity).
 ACT_SITE 168 168 Proton acceptor (Potential).
 BINDING 42 42 NADP (By similarity).
 BINDING 74 74 NADP (By similarity).
 BINDING 172 172 NADP (By similarity).  
Keyword
 Complete proteome; NADP; Oxidoreductase; Peroxisome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 524 AA 
Protein Sequence
MLPNTGKLAG CTVFITGASR GIGKAIALKA AKDGANIVIA AKTTQRHPKL LGTIYTAAEE 60
IEAAGGKALP CVVDVRDEQQ INSAVEKAVE RFGGIDILVN NASAISLTNT LETPTKRVDL 120
MMSVNTRGTY LTSKACIPFL KKSKVAHILN LSPPLNLNPM WFKQHCAYTI AKYGMSMCVL 180
GMAEEFRGEI AVNALWPRTA IHTAAMDMLG GAGVESQCRK VDIIADAAYS IFKRPKSFTG 240
NFIIDENILK EEGIKDFDIY AITPGHPLLP DFFLDEHPDA VMEEKESYDP VPEVKEEKLQ 300
LQEQPQLQEQ PQLQEKPQLQ EQPQLQEKPQ LQEQPQLQEQ PQLQEQPQQQ PQLQEQPQLQ 360
EKPQLQEQPQ QQEKPQPQQQ PQQQPQQRPQ QRPQPQPQPQ PLLQSVLPPK PHFGAVEETF 420
RIVKDSLSDE VVRATQAVYQ FELSGEDGGT WFLDLKSKGG KVGHGEPSDR ADVVMSMATE 480
DFVKMFSGKL KPTMAFMSGK LKIKGNIALA IKLEKLMTHM NSRL 524 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
 GO:0032934; F:sterol binding; IEA:InterPro. 
Interpro
 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR003033; SCP2_sterol-bd_dom. 
Pfam
 PF00106; adh_short
 PF02036; SCP2 
SMART
  
PROSITE
 PS00061; ADH_SHORT 
PRINTS
 PR00081; GDHRDH.