CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020678
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Haloacid dehalogenase-like hydrolase domain-containing protein 3 
Protein Synonyms/Alias
  
Gene Name
 Hdhd3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
15RLLTWDVKDTLIKLRacetylation[1, 2, 3, 4, 5, 6, 7]
15RLLTWDVKDTLIKLRsuccinylation[6]
20DVKDTLIKLRRPVGEacetylation[2, 5]
76LTSRQWWKDVVLHTFacetylation[3, 5, 7]
130GCRKRGLKLAVVSNFacetylation[5]
167SEAVGCPKPDPRIFRacetylation[3, 5]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [6] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [7] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
  
Sequence Annotation
 MOD_RES 15 15 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 251 AA 
Protein Sequence
MAHRLQMRLL TWDVKDTLIK LRRPVGEEYA SKARAHGVVV EDITVEQAFR QAYRAQSHNF 60
PNYGLSRGLT SRQWWKDVVL HTFRLAGVPD AQAMTPVADQ LYEDFSSPFT WQVLEGAEMT 120
LKGCRKRGLK LAVVSNFDRR LEDILTGLGL REHFDFVLTS EAVGCPKPDP RIFREALQRA 180
CVEPAVAAHV GDSYLCDYQG SQAVGMHSFL VAGSEPLDSA VRDSVPKEHI LPSLSHLLPA 240
LDLLEASSPM S 251 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0008967; F:phosphoglycolate phosphatase activity; IEA:InterPro. 
Interpro
 IPR023214; HAD-like_dom.
 IPR011949; HAD-SF_hydro_IA_REG-2-like.
 IPR006439; HAD-SF_hydro_IA_v1.
 IPR006402; HAD-SF_hydro_IA_v3.
 IPR005833; Haloacid_DH/epoxide_hydro. 
Pfam
 PF13419; HAD_2 
SMART
  
PROSITE
  
PRINTS
 PR00413; HADHALOGNASE.