CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004686
UniProt Accession
Genbank Protein ID
 M34238 
Genbank Nucleotide ID
Protein Name
 Nuclear transcription factor Y subunit alpha 
Protein Synonyms/Alias
 CAAT box DNA-binding protein subunit A; CCAAT-binding transcription factor subunit B; CBF-B; Nuclear transcription factor Y subunit A; NF-YA 
Gene Name
 Nfya 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
284AKLEAEGKIPKERRKacetylation[1]
318RFFSPKEKDSPHMQDacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes. 
Sequence Annotation
 DNA_BIND 290 315 NFYA/HAP2-type.
 MOTIF 260 283 Subunit association domain (SAD).
 MOD_RES 320 320 Phosphoserine (By similarity).  
Keyword
 Activator; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 341 AA 
Protein Sequence
MEQYTANSNS STEQIVVQAG QIQQQQQGGV TAVQLQTEAQ VASASGQQVQ TLQVVQGQPL 60
MVQVSGGQLI TSTGQPIMVQ AVPGGQGQTI MQVPVSGTQG LQQIQLVPPG QIQIQGGQAV 120
QVQGQQGQTQ QIIIQQPQTA VTAGQTQTQQ QIAVQGQQVA QTAEGQTIVY QPVNADGTIL 180
QQGMITIPAA SLAGAQIVQT GANTNTTSSG QGTVTVTLPV AGNVVNSGGM VMMVPGAGSV 240
PAIQRIPLPG AEMLEEEPLY VNAKQYHRIL KRRQARAKLE AEGKIPKERR KYLHESRHRH 300
AMARKRGEGG RFFSPKEKDS PHMQDPNQAD EEAMTQIIRV S 341 
Gene Ontology
 GO:0016602; C:CCAAT-binding factor complex; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR018362; CCAAT-binding_factor_CS.
 IPR001289; TF_CBFB. 
Pfam
 PF02045; CBFB_NFYA 
SMART
 SM00521; CBF 
PROSITE
 PS00686; NFYA_HAP2_1
 PS51152; NFYA_HAP2_2 
PRINTS
 PR00616; CCAATSUBUNTB.