CPLM-022484

Genbank Nucleotide ID

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Protein Synonyms/Alias

Cell death regulatory protein GRIM-19; Complex I-B16.6; CI-B16.6; Gene associated with retinoic and interferon-induced mortality 19 protein; GRIM-19; Gene associated with retinoic and IFN-induced mortality 19 protein; NADH-ubiquinone oxidoreductase B16.6 subunit

GRIM19; CDA016; CGI-39

Homo sapiens (Human)

Position	Peptide	Type	References
7	*MAASKVKQDMPPPG	ubiquitination	[1]
22	GYGPIDYKRNLPRRG	ubiquitination	[1, 2]
52	YGHWSIMKWNRERRR	ubiquitination	[1]
99	EEEAIIMKDVPDWKV	ubiquitination	[1, 2, 3, 4]
105	MKDVPDWKVGESVFH	ubiquitination	[2, 3, 4]

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
[2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
[3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.

REGION 102 144 Important for inducing cell death.
MOD_RES 2 2 N-acetylalanine (By similarity).

Acetylation; Apoptosis; Complete proteome; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleus; Polymorphism; Reference proteome; Respiratory chain; Transmembrane; Transmembrane helix; Transport.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
GO:0005654; C:nucleoplasm; IDA:UniProtKB.
GO:0005524; F:ATP binding; NAS:UniProtKB.
GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IDA:UniProtKB.
GO:0030262; P:apoptotic nuclear changes; IDA:UniProtKB.
GO:0097190; P:apoptotic signaling pathway; IDA:UniProtKB.
GO:0006917; P:induction of apoptosis; IMP:UniProtKB.
GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
GO:0006606; P:protein import into nucleus; NAS:UniProtKB.
GO:0072593; P:reactive oxygen species metabolic process; IMP:UniProtKB.
GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
GO:0044281; P:small molecule metabolic process; TAS:Reactome.