| Tag | Content |
|---|
| CPLM ID | CPLM-021648 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lateral signaling target protein 2 homolog |
Protein Synonyms/Alias | hLst2; Zinc finger FYVE domain-containing protein 28 |
Gene Name | ZFYVE28 |
Gene Synonyms/Alias | KIAA1643; LST2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 87 | APRDFCVKFPEEIRH | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. |
Sequence Annotation | ZN_FING 817 879 FYVE-type.
MOD_RES 586 586 Phosphoserine; by MAP2K.
MOD_RES 870 870 Phosphothreonine; by MAP2K.
CROSSLNK 87 87 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Endosome; Isopeptide bond; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 887 AA |
Protein Sequence | MMNRFRKWLY KPKRSDPQLL ARFYYADEEL NQVAAELDSL DGRKDPQRCT LLVSQFRSCQ 60
DNVLNIINQI MDECIPQDRA PRDFCVKFPE EIRHDNLAGQ LWFGAECLAA GSIIMNRELE 120
SMAMRPLAKE LTRSLEDVRG ALRDQALRDL NTYTEKMREA LRHFDVLFAE FELSYVSAMV 180
PVKSPREYYV QQEVIVLFCE TVESGLVVYA DGPLNLDRKV EDMSELFRPF HTLLRKIRDL 240
LQTLTEEELH TLERNLCISQ DVEFPIRADV QGPAALAPAL SAPLPPEGPL SAKAKDPDAE 300
LACSMQYDDQ ELEQLSRMVH RAGDEMSSLL SPPIACQSPA HRPGAEGSPG GEASPGRPRL 360
RSGSDEEERV FFMDDVEGTA EALARPESPA GPFGWAGSTW ADPQEKGQGG PGGAAGISLP 420
ASEKEEDLSN NNLEAEGTDG ASLAGTSSCS CLDSRLHLDG WEVGADDAET AEMIAHRTGG 480
MKLSATVIFN PKSPTSLDSA VATQEAASEP VAEGMDGGPH KLSTGATNCL LHSCVCCGSC 540
GDSREDVVER LREKCSPGGV IGASYAAGLA KASDRAPERQ EEAPPPSEDA SNGREPKAPT 600
SDKCLPHTSG SQVDTASGLQ GEAGVAGQQE PEARELHAGS PSAHEAPQAL SGSSSSTAGS 660
CSSDKMGPEA APAATHAAPQ ATREKIRSRF HGSHDLIHRL FVCISGVADQ LQTNYASDLR 720
SILKTLFEVM ATKPETDDKE KLRKVTQTLR SAALEDCALC QETLSSSELA AKTRDGDFED 780
PPEWVPDEAC GFCTACKAPF TVIRRKHHCR SCGKIFCSRC SSHSAPLPRY GQVKPVRVCT 840
HCYMFHVTPF YSDKAGL 857 |
Gene Ontology | GO:0005829; C:cytosol; IDA:UniProtKB. GO:0031901; C:early endosome membrane; IDA:UniProtKB. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:UniProtKB. GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |