UniProt Accession

 DPY30_MOUSE; Q99LT0 

Genbank Protein ID

 AK003688; AK011643; AK013073; AK077902; BC002240 

Genbank Nucleotide ID

 BAC25047.1; BAC25341.1; BAC25389.1; BAC37054.1; AAH02240.1 

Protein Name

 Protein dpy-30 homolog 

Protein Synonyms/Alias

 Dpy-30-like protein; Dpy-30L 

Gene Name

 Dpy30 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
35	ERIVENEKINAEKSS	ubiquitination	[1]
45	AEKSSKQKVDLQSLP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and histone H3 'Lys- 4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. May also play an indirect or direct role in endosomal transport. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 35 35 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Chromatin regulator; Complete proteome; Golgi apparatus; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 99 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0048188; C:Set1C/COMPASS complex; ISS:UniProtKB.
 GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
 GO:0016197; P:endosomal transport; ISS:UniProtKB.
 GO:0051568; P:histone H3-K4 methylation; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR007858; Dpy-30_motif. 

Pfam

 PF05186; Dpy-30 

SMART

  

PROSITE

  

PRINTS