| Tag | Content |
|---|
| CPLM ID | CPLM-015591 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lysophospholipid acyltransferase 2 |
Protein Synonyms/Alias | LPLAT 2; 1-acylglycerophosphate O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; Lysophosphatidic acid acyltransferase; LPAAT; Lyso-PA acyltransferase; Lysophosphatidylethanolamine acyltransferase; LPEAT; Lyso-PE acyltransferase; Membrane-bound O-acyltransferase domain-containing protein 2; O-acyltransferase domain-containing protein 2 |
Gene Name | MBOAT2 |
Gene Synonyms/Alias | OACT2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 217 | TQSGENGKEETQYER | ubiquitination | [1] | | 472 | VKKTQRRKNTHENIQ | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3- phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2- diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. |
Sequence Annotation | |
Keyword | Acyltransferase; Complete proteome; Lipid biosynthesis; Lipid metabolism; Membrane; Phospholipid biosynthesis; Phospholipid metabolism; Polymorphism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 520 AA |
Protein Sequence | MATTSTTGST LLQPLSNAVQ LPIDQVNFVV CQLFALLAAI WFRTYLHSSK TSSFIRHVVA 60
TLLGLYLALF CFGWYALHFL VQSGISYCIM IIIGVENMHN YCFVFALGYL TVCQVTRVYI 120
FDYGQYSADF SGPMMIITQK ITSLACEIHD GMFRKDEELT SSQRDLAVRR MPSLLEYLSY 180
NCNFMGILAG PLCSYKDYIT FIEGRSYHIT QSGENGKEET QYERTEPSPN TAVVQKLLVC 240
GLSLLFHLTI CTTLPVEYNI DEHFQATASW PTKIIYLYIS LLAARPKYYF AWTLADAINN 300
AAGFGFRGYD ENGAARWDLI SNLRIQQIEM STSFKMFLDN WNIQTALWLK RVCYERTSFS 360
PTIQTFILSA IWHGVYPGYY LTFLTGVLMT LAARAMRNNF RHYFIEPSQL KLFYDVITWI 420
VTQVAISYTV VPFVLLSIKP SLTFYSSWYY CLHILGILVL LLLPVKKTQR RKNTHENIQL 480
SQSKKFDEGE NSLGQNSFST TNNVCNQNQE IASRHSSLKQ 520 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0003841; F:1-acylglycerol-3-phosphate O-acyltransferase activity; IEA:EC. GO:0046474; P:glycerophospholipid biosynthetic process; TAS:Reactome. GO:0036151; P:phosphatidylcholine acyl-chain remodeling; TAS:Reactome. GO:0036152; P:phosphatidylethanolamine acyl-chain remodeling; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |