CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021499
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein RMD5 homolog A 
Protein Synonyms/Alias
  
Gene Name
 RMND5A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
17ELEKVLHKFSGYGQLubiquitination[1, 2]
80QKLASDHKDIHSSVSubiquitination[3]
95RVGKAIDKNFDSDISubiquitination[1]
165NRILEALKVRVLRPAubiquitination[1, 3]
218REALQYAKNFQPFALubiquitination[1, 3, 4, 5]
315CTGVWNQKDELPIEVubiquitination[1, 2]
327IEVDLGKKCWYHSIFubiquitination[1]
365ISRDALNKMFNGSKLubiquitination[1, 4, 5]
373MFNGSKLKCPYCPMEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 DOMAIN 114 146 LisH.
 DOMAIN 153 210 CTLH.  
Keyword
 Alternative splicing; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 391 AA 
Protein Sequence
MDQCVTVERE LEKVLHKFSG YGQLCERGLE ELIDYTGGLK HEILQSHGQD AELSGTLSLV 60
LTQCCKRIKD TVQKLASDHK DIHSSVSRVG KAIDKNFDSD ISSVGIDGCW QADSQRLLNE 120
VMVEHFFRQG MLDVAEELCQ ESGLSVDPSQ KEPFVELNRI LEALKVRVLR PALEWAVSNR 180
EMLIAQNSSL EFKLHRLYFI SLLMGGTTNQ REALQYAKNF QPFALNHQKD IQVLMGSLVY 240
LRQGIENSPY VHLLDANQWA DICDIFTRDA CALLGLSVES PLSVSFSAGC VALPALINIK 300
AVIEQRQCTG VWNQKDELPI EVDLGKKCWY HSIFACPILR QQTTDNNPPM KLVCGHIISR 360
DALNKMFNGS KLKCPYCPME QSPGDAKQIF F 391 
Gene Ontology
  
Interpro
 IPR013144; CRA_dom.
 IPR024964; CTLH/CRA.
 IPR006595; CTLH_C.
 IPR006594; LisH_dimerisation.
 IPR027370; zf-RING_LisH.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF10607; CLTH
 PF13445; zf-RING_LisH 
SMART
 SM00757; CRA
 SM00668; CTLH
 SM00667; LisH 
PROSITE
 PS50897; CTLH
 PS50896; LISH 
PRINTS