CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001208
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ceroid-lipofuscinosis neuronal protein 5 
Protein Synonyms/Alias
 Protein CLN5 
Gene Name
 CLN5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
65KRFDFRPKPDPYCQAubiquitination[1, 2]
105QAPVWEFKYGDLLGHubiquitination[1, 2, 3, 4]
114GDLLGHLKIMHDAIGubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 CARBOHYD 130 130 N-linked (GlcNAc...) (Potential).
 CARBOHYD 143 143 N-linked (GlcNAc...) (Potential).
 CARBOHYD 178 178 N-linked (GlcNAc...) (Potential).
 CARBOHYD 203 203 N-linked (GlcNAc...) (Potential).
 CARBOHYD 255 255 N-linked (GlcNAc...) (Potential).
 CARBOHYD 271 271 N-linked (GlcNAc...) (Potential).
 CARBOHYD 281 281 N-linked (GlcNAc...) (Potential).
 CARBOHYD 352 352 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Disease mutation; Epilepsy; Glycoprotein; Lysosome; Neurodegeneration; Neuronal ceroid lipofuscinosis; Polymorphism; Reference proteome; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 358 AA 
Protein Sequence
MAQEVDTAQG AEMRRGAGAA RGRASWCWAL ALLWLAVVPG WSRVSGIPSR RHWPVPYKRF 60
DFRPKPDPYC QAKYTFCPTG SPIPVMEGDD DIEVFRLQAP VWEFKYGDLL GHLKIMHDAI 120
GFRSTLTGKN YTMEWYELFQ LGNCTFPHLR PEMDAPFWCN QGAACFFEGI DDVHWKENGT 180
LVQVATISGN MFNQMAKWVK QDNETGIYYE TWNVKASPEK GAETWFDSYD CSKFVLRTFN 240
KLAEFGAEFK NIETNYTRIF LYSGEPTYLG NETSVFGPTG NKTLGLAIKR FYYPFKPHLP 300
TKEFLLSLLQ IFDAVIVHKQ FYLFYNFEYW FLPMKFPFIK ITYEEIPLPI RNKTLSGL 358 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IDA:UniProtKB.
 GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0005775; C:vacuolar lumen; IEA:Compara.
 GO:0005537; F:mannose binding; IDA:UniProtKB.
 GO:0007420; P:brain development; IEP:UniProtKB.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0070085; P:glycosylation; IDA:UniProtKB.
 GO:0007042; P:lysosomal lumen acidification; IMP:UniProtKB.
 GO:0042551; P:neuron maturation; NAS:UniProtKB.
 GO:0030163; P:protein catabolic process; NAS:UniProtKB.
 GO:0006465; P:signal peptide processing; IDA:UniProtKB.
 GO:0007601; P:visual perception; IEA:Compara. 
Interpro
 IPR026138; CLN5. 
Pfam
  
SMART
  
PROSITE
  
PRINTS