| Tag | Content |
|---|
| CPLM ID | CPLM-012553 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Splicing factor 3B subunit 3 |
Protein Synonyms/Alias | Pre-mRNA-splicing factor SF3b 130 kDa subunit; SF3b130; STAF130; Spliceosome-associated protein 130; SAP 130 |
Gene Name | SF3B3 |
Gene Synonyms/Alias | KIAA0017; SAP130 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 124 | EKLEFLHKTPVEEVP | ubiquitination | [1] | | 147 | RVLIGVGKLLRVYDL | ubiquitination | [1] | | 256 | DEDPTGNKALWDRGL | ubiquitination | [1] | | 388 | RTPPEVSKKLEDIRT | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. |
Sequence Annotation | |
Keyword | Alternative splicing; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Polymorphism; Reference proteome; Spliceosome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1217 AA |
Protein Sequence | MAEEMVEAAG EDERELAAEM AAAFLNENLP ESIFGAPKAG NGQWASVIRV MNPIQGNTLD 60
LVQLEQNEAA FSVAVCRFSN TGEDWYVLVG VAKDLILNPR SVAGGFVYTY KLVNNGEKLE 120
FLHKTPVEEV PAAIAPFQGR VLIGVGKLLR VYDLGKKKLL RKCENKHIAN YISGIQTIGH 180
RVIVSDVQES FIWVRYKRNE NQLIIFADDT YPRWVTTASL LDYDTVAGAD KFGNICVVRL 240
PPNTNDEVDE DPTGNKALWD RGLLNGASQK AEVIMNYHVG ETVLSLQKTT LIPGGSESLV 300
YTTLSGGIGI LVPFTSHEDH DFFQHVEMHL RSEHPPLCGR DHLSFRSYYF PVKNVIDGDL 360
CEQFNSMEPN KQKNVSEELD RTPPEVSKKL EDIRTRYAF 399 |
Gene Ontology | GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB. GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0030532; C:small nuclear ribonucleoprotein complex; TAS:ProtInc. GO:0005689; C:U12-type spliceosomal complex; IDA:UniProtKB. GO:0003676; F:nucleic acid binding; IEA:InterPro. GO:0000398; P:mRNA splicing, via spliceosome; IC:UniProtKB. GO:0006461; P:protein complex assembly; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |