CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027445
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heat shock protein 60 
Protein Synonyms/Alias
  
Gene Name
 PF10_0153 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
246DQKVELDKPYILIHEacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Complete proteome; Nucleotide-binding; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 580 AA 
Protein Sequence
MISTLRGKIF NNGSNRNKCV SILSNIQKRN ISKDIRFGSD ARTAMLTGCN KLADAVSVTL 60
GPKGRNVIIE QSFGSPKITK DGVTVAKSIE FNNKLANLGA QMVKQVAANT NDKAGDGTTT 120
ATILARSIFQ QGCKAVDSGM NPMDLLRGIN KGVEKVLEYL NSIKKDVTTT EEIFNVASIS 180
ANGDKNIGQL IADTMKKVGK EGTITVTEGK TLQHELEIVE GIKFDRGYIS PYFINNSKDQ 240
KVELDKPYIL IHEKKISTVK SLLPVLEHVL QNQSSLLVIA EDVDSDALAT LIVNKLRLGL 300
KICAVKAPGF GEHRKALIHD IAVMTGAKVI TEETGLKLDD PQVVSYLGKA KSINVTKDST 360
LIMEGEGKKE EINERCESIR NAIKMNTSDY EKEKLQERLA KITGGVALIK VGGISEVEVN 420
EIKDRIQDAL CATKAAVEEG IVPGGGSALL FASKELDSVQ TDNYDQRVGV NIIKDACKAP 480
IKQIAENAGH EGSVVAGNIL KEKNSNIGFN AQEGKYVDMI ESGIIDPTKV VKTAISDAAS 540
IASLMTTTEV AIVDFKDSKN EESSQHMNSV NSMGDMGGMY 580 
Gene Ontology
 GO:0005739; C:mitochondrion; ISS:GeneDB_Pfalciparum.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042623; F:ATPase activity, coupled; ISS:GeneDB_Pfalciparum.
 GO:0042026; P:protein refolding; IEA:InterPro.
 GO:0006626; P:protein targeting to mitochondrion; ISS:GeneDB_Pfalciparum.
 GO:0006986; P:response to unfolded protein; ISS:GeneDB_Pfalciparum. 
Interpro
 IPR018370; Chaperonin_Cpn60_CS.
 IPR001844; Chaprnin_Cpn60.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00296; CHAPERONINS_CPN60 
PRINTS
 PR00298; CHAPERONIN60.