UniProt Accession

 HDGF_RAT; Q8VHK7; Q923W3 

Genbank Protein ID

 AF448810; AF389348; BC070943 

Genbank Nucleotide ID

 AAL47132.1; AAK72966.1; AAH70943.1 

Protein Name

 Hepatoma-derived growth factor 

Protein Synonyms/Alias

 HDGF 

Gene Name

 Hdgf 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
180	GDHEEEEKEIAALEG	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor (By similarity). 

Sequence Annotation

 DOMAIN 12 69 PWWP.
 MOTIF 75 80 Nuclear localization signal (By
 MOTIF 155 170 Bipartite nuclear localization signal (By
 BINDING 19 19 Heparin (By similarity).
 BINDING 21 21 Heparin (By similarity).
 BINDING 72 72 Heparin (By similarity).
 BINDING 75 75 Heparin (By similarity).
 BINDING 79 79 Heparin (By similarity).
 BINDING 80 80 Heparin (By similarity).
 MOD_RES 44 44 N6-acetyllysine (By similarity).
 MOD_RES 132 132 Phosphoserine.
 MOD_RES 133 133 Phosphoserine.
 MOD_RES 165 165 Phosphoserine.
 MOD_RES 199 199 Phosphoserine (By similarity).
 MOD_RES 200 200 Phosphothreonine (By similarity).
 MOD_RES 202 202 Phosphoserine (By similarity).
 MOD_RES 206 206 Phosphoserine (By similarity).
 MOD_RES 236 236 Phosphoserine (By similarity).
 CROSSLNK 80 80 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Growth factor; Heparin-binding; Isopeptide bond; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 237 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0034504; P:protein localization to nucleus; IDA:BHF-UCL.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000313; PWWP. 

Pfam

 PF00855; PWWP 

SMART

 SM00293; PWWP 

PROSITE

 PS50812; PWWP 

PRINTS