UniProt Accession

 ELMD2_HUMAN; Q8IZ81; B2R712; D3DNZ0 

Genbank Protein ID

 AK312800; CH471056; CH471056; BC015168 

Genbank Nucleotide ID

 BAG35659.1; EAX05096.1; EAX05097.1; AAH15168.2 

Protein Name

 ELMO domain-containing protein 2 

Protein Synonyms/Alias

  

Gene Name

 ELMOD2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
55	ENSLTYSKNKVLQKA	ubiquitination	[1, 2]
57	SLTYSKNKVLQKATH	ubiquitination	[2]
61	SKNKVLQKATHVVQS	ubiquitination	[1, 3, 4, 5]
150	KLNARISKQWAEIGF	ubiquitination	[1, 2, 3, 4, 5]
163	GFQGDDPKTDFRGMG	ubiquitination	[4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses. 

Sequence Annotation

 DOMAIN 126 282 ELMO.  

Keyword

 Antiviral defense; Complete proteome; GTPase activation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 293 AA 

Protein Sequence

Gene Ontology

 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0005096; F:GTPase activator activity; IDA:UniProtKB.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0006909; P:phagocytosis; IEA:InterPro.
 GO:0050688; P:regulation of defense response to virus; IDA:UniProtKB. 

Interpro

 IPR006816; Engulfment_cell_motility_ELMO. 

Pfam

 PF04727; ELMO_CED12 

SMART

  

PROSITE

 PS51335; ELMO 

PRINTS