CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012246
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 
Protein Synonyms/Alias
 Cam-PDE 1C; hCam-3 
Gene Name
 PDE1C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
695KMLDQRIKMKKIQNImethylation[1]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
 Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. 
Sequence Annotation
 REGION 202 521 Catalytic (By similarity).
 ACT_SITE 228 228 Proton donor (By similarity).
 METAL 232 232 Divalent metal cation 1 (By similarity).
 METAL 268 268 Divalent metal cation 1 (By similarity).
 METAL 269 269 Divalent metal cation 1 (By similarity).
 METAL 269 269 Divalent metal cation 2 (By similarity).
 METAL 376 376 Divalent metal cation 1 (By similarity).
 MOD_RES 1 1 N-acetylmethionine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Calmodulin-binding; cAMP; cGMP; Complete proteome; Hydrolase; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 709 AA 
Protein Sequence
MESPTKEIEE FESNSLKYLQ PEQIEKIWLR LRGLRKYKKT SQRLRSLVKQ LERGEASVVD 60
LKKNLEYAAT VLESVYIDET RRLLDTEDEL SDIQSDAVPS EVRDWLASTF TRQMGMMLRR 120
SDEKPRFKSI VHAVQAGIFV ERMYRRTSNM VGLSYPPAVI EALKDVDKWS FDVFSLNEAS 180
GDHALKFIFY ELLTRYDLIS RFKIPISALV SFVEALEVGY SKHKNPYHNL MHAADVTQTV 240
HYLLYKTGVA NWLTELEIFA IIFSAAIHDY EHTGTTNNFH IQTRSDPAIL YNDRSVLENH 300
HLSAAYRLLQ DDEEMNILIN LSKDDWREFR TLVIEMVMAT DMSCHFQQIK AMKTALQQPE 360
AIEKPKALSL MLHTADISHP AKAWDLHHRW TMSLLEEFFR QGDREAELGL PFSPLCDRKS 420
TMVAQSQVGF IDFIVEPTFT VLTDMTEKIV SPLIDETSQT GGTGQRRSSL NSISSSDAKR 480
SGVKTSGSEG SAPINNSVIS VDYKSFKATW TEVVHINRER WRAKVPKEEK AKKEAEEKAR 540
LAAEEQQKEM EAKSQAEEGA SGKAEKKTSG ETKNQVNGTR ANKSDNPRGK NSKAEKSSGE 600
QQQNGDFKDG KNKTDKKDHS NIGNDSKKTD GTKQRSHGSP APSTSSTCRL TLPVIKPPLR 660
HFKRPAYASS SYAPSVSKKT DEHPARYKML DQRIKMKKIQ NISHNWNRK 709 
Gene Ontology
 GO:0005929; C:cilium; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004117; F:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007202; P:activation of phospholipase C activity; TAS:Reactome.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0007608; P:sensory perception of smell; IEA:Compara. 
Interpro
 IPR003607; HD/PDEase_dom.
 IPR023088; PDEase.
 IPR002073; PDEase_catalytic_dom.
 IPR023174; PDEase_CS.
 IPR013706; PDEase_N. 
Pfam
 PF00233; PDEase_I
 PF08499; PDEase_I_N 
SMART
 SM00471; HDc 
PROSITE
 PS00126; PDEASE_I 
PRINTS
 PR00387; PDIESTERASE1.