CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012972
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial 10-formyltetrahydrofolate dehydrogenase 
Protein Synonyms/Alias
 Mitochondrial 10-FTHFDH; mtFDH; Aldehyde dehydrogenase family 1 member L2 
Gene Name
 ALDH1L2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
70PLALAAEKDGTPVFKacetylation[1]
227ATYEGIQKKENAEISacetylation[1]
886VFINTYNKTDVAAPFacetylation[2]
903VKQSGFGKDLGEEALacetylation[1, 2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
  
Sequence Annotation
 DOMAIN 344 413 Acyl carrier.
 REGION 23 225 GART.
 REGION 438 923 Aldehyde dehydrogenase.
 ACT_SITE 128 128 Proton donor (By similarity).
 ACT_SITE 694 694 By similarity.
 ACT_SITE 728 728 By similarity.
 MOD_RES 375 375 O-(pantetheine 4'-phosphoryl)serine (By
 MOD_RES 903 903 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Mitochondrion; NADP; One-carbon metabolism; Oxidoreductase; Phosphopantetheine; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 923 AA 
Protein Sequence
MLRRGSQALR RFSTGRVYFK NKLKLALIGQ SLFGQEVYSH LRKEGHRVVG VFTVPDKDGK 60
ADPLALAAEK DGTPVFKLPK WRVKGKTIKE VAEAYRSVGA ELNVLPFCTQ FIPMDIIDSP 120
KHGSIIYHPS ILPRHRGASA INWTLIMGDK KAGFSVFWAD DGLDTGPILL QRSCDVEPND 180
TVDALYNRFL FPEGIKAMVE AVQLIADGKA PRIPQPEEGA TYEGIQKKEN AEISWDQSAE 240
VLHNWIRGHD KVPGAWTEIN GQMVTFYGST LLNSSVPPGE PLEIKGAKKP GLVTKNGLVL 300
FGNDGKALTV RNLQFEDGKM IPASQYFSTG ETSVVELTAE EVKVAETIKV IWAGILSNVP 360
IIEDSTDFFK SGASSMDVAR LVEEIRQKCG GLQLQNEDVY MATKFEGFIQ KVVRKLRGED 420
QEVELVVDYI SKEVNEIMVK MPYQCFINGQ FTDADDGKTY DTINPTDGST ICKVSYASLA 480
DVDKAVAAAK DAFENGEWGR MNARERGRLM YRLADLLEEN QEELATIEAL DSGAVYTLAL 540
KTHIGMSVQT FRYFAGWCDK IQGSTIPINQ ARPNRNLTFT KKEPLGVCAI IIPWNYPLMM 600
LAWKSAACLA AGNTLVLKPA QVTPLTALKF AELSVKAGFP KGVINIIPGS GGIAGQRLSE 660
HPDIRKLGFT GSTPIGKQIM KSCAVSNLKK VSLELGGKSP LIIFNDCELD KAVRMGMGAV 720
FFNKGENCIA AGRLFVEESI HDEFVTRVVE EIKKMKIGDP LDRSTDHGPQ NHKAHLEKLL 780
QYCETGVKEG ATLVYGGRQV QRPGFFMEPT VFTDVEDYMY LAKEESFGPI MVISKFQNGD 840
IDGVLQRANS TEYGLASGVF TRDINKAMYV SEKLEAGTVF INTYNKTDVA APFGGVKQSG 900
FGKDLGEEAL NEYLKTKTVT LEY 923 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0016155; F:formyltetrahydrofolate dehydrogenase activity; IEA:EC.
 GO:0016742; F:hydroxymethyl-, formyl- and related transferase activity; IEA:InterPro.
 GO:0008168; F:methyltransferase activity; IEA:InterPro.
 GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
 GO:0009258; P:10-formyltetrahydrofolate catabolic process; IEA:InterPro.
 GO:0009058; P:biosynthetic process; IEA:InterPro.
 GO:0032259; P:methylation; IEA:GOC.
 GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. 
Interpro
 IPR011407; 10_FTHF_DH.
 IPR009081; Acyl_carrier_prot-like.
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR005793; Formyl_trans_C.
 IPR002376; Formyl_transf_N.
 IPR011034; Formyl_transferase_C-like.
 IPR001555; GART_AS.
 IPR006162; PPantetheine_attach_site. 
Pfam
 PF00171; Aldedh
 PF02911; Formyl_trans_C
 PF00551; Formyl_trans_N
 PF00550; PP-binding 
SMART
  
PROSITE
 PS50075; ACP_DOMAIN
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU
 PS00373; GART
 PS00012; PHOSPHOPANTETHEINE 
PRINTS