UniProt Accession

 ARPC3_YEAST; Q05933; D6VZ07 

Genbank Protein ID

 U19103; AY558319; BK006945 

Genbank Nucleotide ID

 AAB67576.1; AAS56645.1; DAA09673.1 

Protein Name

 Actin-related protein 2/3 complex subunit 3 

Protein Synonyms/Alias

 Arp2/3 complex 21 kDa subunit; p21-ARC 

Gene Name

 ARC18 

Gene Synonyms/Alias

 YLR370C; L8039.15 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
29	ALLPLNTKFRGPAYP	ubiquitination	[1, 2]
58	FRANSFFKNFEIKSP	acetylation	[3]
63	FFKNFEIKSPADRVL	acetylation	[3]
63	FFKNFEIKSPADRVL	ubiquitination	[2]
158	VYSSTDSKEYPSKFW	ubiquitination	[2]

Reference

 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). 

Sequence Annotation

  

Keyword

 Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 178 AA 

Protein Sequence

Gene Ontology

 GO:0005885; C:Arp2/3 protein complex; IDA:SGD.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0007015; P:actin filament organization; IMP:SGD.
 GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro.
 GO:0051654; P:establishment of mitochondrion localization; IMP:SGD.
 GO:0000001; P:mitochondrion inheritance; TAS:SGD. 

Interpro

 IPR007204; ARP2/3_p21-Arc. 

Pfam

 PF04062; P21-Arc 

SMART

  

PROSITE

  

PRINTS