UniProt Accession

 E7EWY2_HUMAN; E7EWY2 

Genbank Protein ID

 D87012 

Genbank Nucleotide ID

  

Protein Name

 DNA topoisomerase 

Protein Synonyms/Alias

  

Gene Name

 TOP3B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
10	LNMTKLEKEAQVEAT	ubiquitination	[1]
80	YPENFDLKGSLRQQA	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; DNA-binding; Isomerase; Reference proteome; Topoisomerase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 282 AA 

Protein Sequence

Gene Ontology

 GO:0005694; C:chromosome; IEA:InterPro.
 GO:0003917; F:DNA topoisomerase type I activity; IEA:EC.
 GO:0006265; P:DNA topological change; IEA:InterPro. 

Interpro

 IPR000380; Topo_IA.
 IPR023406; Topo_IA_AS.
 IPR013497; Topo_IA_cen.
 IPR013824; Topo_IA_cen_sub1.
 IPR013826; Topo_IA_cen_sub3.
 IPR023405; Topo_IA_core_domain.
 IPR003602; Topo_IA_DNA-bd. 

Pfam

 PF01131; Topoisom_bac 

SMART

 SM00437; TOP1Ac 

PROSITE

 PS00396; TOPOISOMERASE_I_PROK 

PRINTS