CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044944
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Hsp90 co-chaperone Cdc37 
Protein Synonyms/Alias
  
Gene Name
 CDC37 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
129MLQDAISKMDPTDAKubiquitination[1]
136KMDPTDAKYHMQRCIacetylation[2]
136KMDPTDAKYHMQRCIubiquitination[2, 3, 4]
153GLWVPNSKASEAKEGubiquitination[2, 4]
158NSKASEAKEGEEAGPubiquitination[1, 2]
180VPKTGDEKDVSV***ubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 184 AA 
Protein Sequence
XYLVIWCIDL EVEEKCALME QVAHQTIVMQ FILELAKSLK VDPRACFRQF FTKIKTADRQ 60
YMEGFNDELE AFKERVRGRA KLRIEKAMKE YEEEERKKRL GPGGLDPVEE LQKCFDVKDV 120
QMLQDAISKM DPTDAKYHMQ RCIDSGLWVP NSKASEAKEG EEAGPGDPLL EAVPKTGDEK 180
DVSV 184 
Gene Ontology
  
Interpro
 IPR004918; Cdc37.
 IPR013873; Cdc37_C.
 IPR013874; Cdc37_Hsp90-bd. 
Pfam
 PF08564; CDC37_C
 PF08565; CDC37_M 
SMART
 SM01069; CDC37_C
 SM01070; CDC37_M 
PROSITE
  
PRINTS