UniProt Accession

 PMU1_YEAST; P36069; D6VX67; E9P8Y9 

Genbank Protein ID

 Z28128; AY692900; BK006944 

Genbank Nucleotide ID

 CAA81969.1; AAT92919.1; DAA09033.1 

Protein Name

 Probable phosphomutase PMU1 

Protein Synonyms/Alias

  

Gene Name

 PMU1 

Gene Synonyms/Alias

 YKL128C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
38	LINHKNWKELYHAIP	acetylation	[1]
179	LGSHTCDKRVAHSMA	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Probable phosphomutase that may have a function related to the manipulation of phosphate groups on carbohydrates. Reduces trehalose-6-phosphate levels when overexpressed in TPS2-deleted cells. Reduces 5'-Phosphoribosyl-4-carboxamide-5-aminoimidazole (AICAR) levels, a metabolic intermediate at the crossroads between AMP and histidine biosynthesis pathways, when overexpressed in a ADE3-ADE16-ADE17 triple deletant. 

Sequence Annotation

 ACT_SITE 61 61 Tele-phosphohistidine intermediate (By  

Keyword

 Complete proteome; Cytoplasm; Isomerase; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0016853; F:isomerase activity; IEA:UniProtKB-KW. 

Interpro

 IPR013078; His_Pase_superF_clade-1. 

Pfam

 PF00300; His_Phos_1 

SMART

 SM00855; PGAM 

PROSITE

 PS00175; PG_MUTASE 

PRINTS