| Tag | Content |
|---|
| CPLM ID | CPLM-014195 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | LETM1 and EF-hand domain-containing protein 1, mitochondrial |
Protein Synonyms/Alias | Leucine zipper-EF-hand-containing transmembrane protein 1 |
Gene Name | Letm1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 161 | QKILDELKHYYHGFR | acetylation | [1] | | 256 | LKKELRVKLELAKFL | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization (By similarity). |
Sequence Annotation | DOMAIN 149 417 LETM1.
DOMAIN 663 698 EF-hand.
MOD_RES 596 596 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Calcium; Coiled coil; Complete proteome; Direct protein sequencing; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transit peptide; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 739 AA |
Protein Sequence | MASILLRSCR GRGPARLASP RAASPRGSLR DRACLSCTRT VGLTSHESVL SRCCTPANPV 60
YLYFKSEPLS CWTQRPECQG TVARAAWTPA SARLVVTGPQ YLPVRGWHSS SPLGEDSMIE 120
KSLKSLKDKN KKLEEGGPVY SPPAQVVVKK SLGQKILDEL KHYYHGFRLL WIDTKIAARM 180
LWRILNGHTL TRRERRQFLR ICADLFRLVP FLVFVVVPFM EFLLPVVVKL FPNMLPSTFE 240
TQSIKEERLK KELRVKLELA KFLQDTIEEM ALKNKAAKGN ATKDFSAFFQ KIRETGERPS 300
NEEIMRFSKL FEDELTLDNL TRPQLVALCK LLELQSIGTN NFLRFQLTMR LRSIKADDKL 360
ISEEGVDSLT VKELQAACRA RGMRALGVTE DRLKGQLKQW LDLHLYHEIP TSLLILSRAM 420
YLPDTLSPAD QLKSTLQTLP EIVAKEAQVK AAEVEGEQVD NKAKLEATLQ EEAAIQQEHL 480
EELKRAAETA KDIQPEVAEA TVPGRPGAEL QPKMVDVIPP SEILKDTAPV LEGLKGEEIT 540
KEEIDILSDA CSKLKEQKKS LTKEKEELEL LKEDVQDYSE DLQEIKKELS KTGDEKYIEE 600
STASKRLSKR VQQMIGQIDG LITQLETTQQ NGKLDPAAAS SPTGESVISV DELISAMKQI 660
KHIPEHKLIS LTSALDENKD GNINIDDLVK VIDLVNKEDV QISTTQVAEI VATLEKEEKV 720
EEKEKAKEKA EKEAAEVKN 739 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0042407; P:cristae formation; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |