CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021331
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sorting nexin-25 
Protein Synonyms/Alias
  
Gene Name
 SNX25 
Gene Synonyms/Alias
 MSTP043 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
197NSDVEFLKQLRYQIVubiquitination[1, 2]
584SLSKLPFKSIDQKFMacetylation[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May be involved in several stages of intracellular trafficking (By similarity). 
Sequence Annotation
 DOMAIN 1 164 PXA.
 DOMAIN 287 401 RGS.
 DOMAIN 508 628 PX.
 MOD_RES 665 665 Phosphoserine.  
Keyword
 Coiled coil; Complete proteome; Endosome; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 840 AA 
Protein Sequence
MDKALKEVFD YSYRDYILSW YGNLSRDEGQ LYHLLLEDFW EIARQLHHRL SHVDVVKVVC 60
NDVVRTLLTH FCDLKAANAR HEEQPRPFVL HACLRNSDDE VRFLQTCSRV LVFCLLPSKD 120
VQSLSLRIML AEILTTKVLK PVVELLSNPD YINQMLLAQL AYREQMNEHH KRAYTYAPSY 180
EDFIKLINSN SDVEFLKQLR YQIVVEIIQA TTISSFPQLK RHKGKETAAM KADLLRARNM 240
KRYINQLTVA KKQCEKRIRI LGGPAYDQQE DGALDEGEGP QSQKILQFED ILANTFYREH 300
FGMYMERMDK RALISFWESV EHLKNANKNE IPQLVGEIYQ NFFVESKEIS VEKSLYKEIQ 360
QCLVGNKGIE VFYKIQEDVY ETLKDRYYPS FIVSDLYEKL LIKEEEKHAS QMISNKDEMG 420
PRDEAGEEAV DDGTNQINEQ ASFAVNKLRE LNEKLEYKRQ ALNSIQNAPK PDKKIVSKLK 480
DEIILIEKER TDLQLHMART DWWCENLGMW KASITSGEVT EENGEQLPCY FVMVSLQEVG 540
GVETKNWTVP RRLSEFQNLH RKLSECVPSL KKVQLPSLSK LPFKSIDQKF MEKSKNQLNK 600
FLQNLLSDER LCQSEALYAF LSPSPDYLKV IDVQGKKNSF SLSSFLERLP RDFFSHQEEE 660
TEEDSDLSDY GDDVDGRKDA LAEPCFMLIG EIFELRGMFK WVRRTLIALV QVTFGRTINK 720
QIRDTVSWIF SEQMLVYYIN IFRDAFWPNG KLAPPTTIRS KEQSQETKQR AQQKLLENIP 780
DMLQSLVGQQ NARHGIIKIF NALQETRANK HLLYALMELL LIELCPELRV HLDQLKAGQV 840 
Gene Ontology
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. 
Interpro
 IPR001683; Phox.
 IPR003114; Phox_assoc.
 IPR000342; Regulat_G_prot_signal.
 IPR016137; Regulat_G_prot_signal_superfam.
 IPR013937; Sorting_nexin_C. 
Pfam
 PF08628; Nexin_C
 PF00787; PX
 PF02194; PXA
 PF00615; RGS 
SMART
 SM00312; PX
 SM00315; RGS 
PROSITE
 PS50195; PX
 PS51207; PXA
 PS50132; RGS 
PRINTS