CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007032
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Clathrin coat assembly protein AP180A 
Protein Synonyms/Alias
  
Gene Name
 YAP1801 
Gene Synonyms/Alias
 YHR161C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
135RDGYRTLKLNSGNYGubiquitination[1]
274EHLIEDDKTHNTFVPubiquitination[1]
295SAGAVVAKSTAQERLubiquitination[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 
Functional Description
 Involved in endocytosis and clathrin cage assembly. 
Sequence Annotation
 DOMAIN 1 126 ENTH.
 REGION 587 637 Clathrin-binding.  
Keyword
 Cell membrane; Complete proteome; Cytoplasm; Endocytosis; Membrane; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 637 AA 
Protein Sequence
MTTYFKLVKG ATKIKSAPPK QKYLDPILLG TSNEEDFYEI VKGLDSRIND TAWTIVYKSL 60
LVVHLMIREG SKDVALRYYS RNLEFFDIEN IRGSNGSASG DMRALDRYDN YLKVRCREFG 120
KIKKDYVRDG YRTLKLNSGN YGSSRNKQHS INIALDHVES LEVQIQALIK NKYTQYDLSN 180
ELIIFGFKLL IQDLLALYNA LNEGIITLLE SFFELSHHNA ERTLDLYKTF VDLTEHVVRY 240
LKSGKTAGLK IPVIKHITTK LVRSLEEHLI EDDKTHNTFV PVDSSQGSAG AVVAKSTAQE 300
RLEQIREQKR ILEAQLKNEQ VAISPALTTV TAAQSYNPFG TDSSMHTNIP MAVANQTQQI 360
ANNPFVSQTQ PQVMNTPTAH TEPANLNVPE YAAVQHTVNF NPVQDAGVSA QQTGYYSINN 420
HLTPTFTGAG FGGYSVSQDT TAASNQQVSH SQTGSNNPFA LHNAATIATG NPAHENVLNN 480
PFSRPNFDEQ NTNMPLQQQI ISNPFQNQTY NQQQFQQQKM PLSSINSVMT TPTSMQGSMN 540
IPQRFDKMEF QAHYTQNHLQ QQQQQQQQQQ QQQQQQPQQG YYVPATAGAN PVTNITGTVQ 600
PQNFPFYPQQ QPQPEQSQTQ QPVLGNQYAN NLNLIDM 637 
Gene Ontology
 GO:0030479; C:actin cortical patch; TAS:SGD.
 GO:0005935; C:cellular bud neck; IEA:UniProtKB-SubCell.
 GO:0030118; C:clathrin coat; IEA:InterPro.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005545; F:1-phosphatidylinositol binding; IEA:InterPro.
 GO:0030276; F:clathrin binding; TAS:SGD.
 GO:0048268; P:clathrin coat assembly; IEA:InterPro.
 GO:0006897; P:endocytosis; IPI:SGD. 
Interpro
 IPR011417; ANTH_dom.
 IPR014712; Clathrin_Pinositid-bd_GAT-like.
 IPR008942; ENTH_VHS.
 IPR013809; Epsin-like_N. 
Pfam
 PF07651; ANTH 
SMART
 SM00273; ENTH 
PROSITE
 PS50942; ENTH 
PRINTS