CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013272
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Annexin A8 
Protein Synonyms/Alias
 Annexin VIII; Annexin-8 
Gene Name
 Anxa8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
32PDAETLYKAMKGIGTacetylation[1]
69SFKAQFGKDLTETLKacetylation[1]
76KDLTETLKSELSGKFacetylation[1]
82LKSELSGKFERLIVAacetylation[1]
292EIDLNLIKSQFQKMYacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade (By similarity). 
Sequence Annotation
 REPEAT 38 90 Annexin 1.
 REPEAT 110 162 Annexin 2.
 REPEAT 195 247 Annexin 3.
 REPEAT 270 322 Annexin 4.
 METAL 266 266 Calcium; via carbonyl oxygen (By
 METAL 268 268 Calcium; via carbonyl oxygen (By
 METAL 270 270 Calcium; via carbonyl oxygen (By
 METAL 310 310 Calcium (By similarity).  
Keyword
 Annexin; Blood coagulation; Calcium; Calcium/phospholipid-binding; Complete proteome; Direct protein sequencing; Hemostasis; Metal-binding; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 327 AA 
Protein Sequence
MAWWKAWVEQ EGVSVKGSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK RSNVQRQQIA 60
KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYRYEAK ELHDAMKGLG TKEGVIIEIL 120
ASRTKNQLRE IMKAYEEDYG STLEEDIQGD TSGYLERILV CLLQGCRDDV SGFVDPGLAL 180
QDAQDLHAAG EKILGTDEMK FITILCTRSA THLMRVFEEY EKIANKSIED SIKSETHGSL 240
EEAMLTVVKC TRNVHSYFAE RLYYAMKGAG TLDGTLIRNI VSRSEIDLNL IKSQFQKMYG 300
KTLSSMIMGD TSGYYKTALL NLVGTDL 327 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
 GO:0007596; P:blood coagulation; IEA:UniProtKB-KW. 
Interpro
 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR009115; AnnexinVIII. 
Pfam
 PF00191; Annexin 
SMART
 SM00335; ANX 
PROSITE
 PS00223; ANNEXIN 
PRINTS
 PR00196; ANNEXIN.
 PR01808; ANNEXINVIII.