Tag | Content |
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CPLM ID | CPLM-019483 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dedicator of cytokinesis protein 7 |
Protein Synonyms/Alias | |
Gene Name | DOCK7 |
Gene Synonyms/Alias | KIAA1771 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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177 | QDDQDDLKRRSMSID | ubiquitination | [1] | 233 | QRKSNRHKELFALHP | ubiquitination | [1] | 366 | AEPYMIFKEADATKN | ubiquitination | [1] | 532 | TPELLQVKLYPDSRV | ubiquitination | [1] | 922 | VRSIIGSKAMDRSCN | ubiquitination | [1] |
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Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. |
Sequence Annotation | DOMAIN 561 727 DHR-1. DOMAIN 1678 2114 DHR-2. MOD_RES 28 28 Phosphoserine. MOD_RES 30 30 Phosphoserine. MOD_RES 180 180 Phosphoserine. MOD_RES 182 182 Phosphoserine. MOD_RES 439 439 Phosphoserine (By similarity). MOD_RES 440 440 Phosphoserine (By similarity). MOD_RES 882 882 Phosphoserine. MOD_RES 888 888 Phosphoserine. MOD_RES 896 896 Phosphoserine. MOD_RES 900 900 Phosphoserine. MOD_RES 905 905 Phosphoserine. MOD_RES 907 907 Phosphothreonine. MOD_RES 909 909 Phosphothreonine. MOD_RES 910 910 Phosphoserine. MOD_RES 964 964 Phosphoserine (By similarity). MOD_RES 966 966 Phosphothreonine (By similarity). MOD_RES 1383 1383 Phosphoserine. MOD_RES 1430 1430 Phosphoserine. MOD_RES 1432 1432 Phosphoserine. MOD_RES 1438 1438 Phosphoserine. MOD_RES 1962 1962 N6-acetyllysine. |
Keyword | Acetylation; Alternative splicing; Cell projection; Coiled coil; Complete proteome; Developmental protein; Differentiation; Guanine-nucleotide releasing factor; Neurogenesis; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2140 AA |
Protein Sequence | MAERRAFAQK ISRTVAAEVR KQISGQYSGS PQLLKNLNIV GNISHHTTVP LTEAVDPVDL 60 EDYLITHPLA VDSGPLRDLI EFPPDDIEVV YSPRDCRTLV SAVPEESEMD PHVRDCIRSY 120 TEDWAIVIRK YHKLGTGFNP NTLDKQKERQ KGLPKQVFES DEAPDGNSYQ DDQDDLKRRS 180 MSIDDTPRGS WACSIFDLKN SLPDALLPNL LDRTPNEEID RQNDDQRKSN RHKELFALHP 240 SPDEEEPIER LSVPDIPKEH FGQRLLVKCL SLKFEIEIEP IFASLALYDV KEKKKISENF 300 YFDLNSEQMK GLLRPHVPPA AITTLARSAI FSITYPSQDV FLVIKLEKVL QQGDIGECAE 360 PYMIFKEADA TKNKEKLEKL KSQADQFCQR LGKYRMPFAW TAIHLMNIVS SAGSLERDST 420 EVEISTGERK GSWSERRNSS IVGRRSLERT TSGDDACNLT SFRPATLTVT NFFKQEGDRL 480 SDEDLYKFLA DMRRPSSVLR RLRPITAQLK IDISPAPENP HYCLTPELLQ VKLYPDSRVR 540 PTREILEFPA RDVYVPNTTY RNLLYIYPQS LNFANRQGSA RNITVKVQFM YGEDPSNAMP 600 VIFGKSSCSE FSKEAYTAVV YHNRSPDFHE EIKVKLPATL TDHHHLLFTF YHVSCQQKQN 660 TPLETPVGYT WIPMLQNGRL KTGQFCLPVS LEKPPQAYSV LSPEVPLPGM KWVDNHKGVF 720 NVEVVAVSSI HTQDPYLDKF FALVNALDEH LFPVRIGDMR IMENNLENEL KSSISALNSS 780 QLEPVVRFLH LLLDKLILLV IRPPVIAGQI VNLGQASFEA MASIINRLHK NLEGNHDQHG 840 RNSLLASYIH YVFRLPNTYP NSSSPGPGGL GGSVHYATMA RSAVRPASLN LNRSRSLSNS 900 NPDISGTPTS PDDEVRSIIG SKAMDRSCNR MSSHTETSSF LQTLTGRLPT KKLFHEELAL 960 QWVVCSGSVR ESALQQAWFF FELMVKSMVH HLYFNDKLEA PRKSRFPERF MDDIAALVST 1020 IASDIVSRFQ KDTEMVERLN TSLAFFLNDL LSVMDRGFVF SLIKSCYKQV SSKLYSLPNP 1080 SVLVSLRLDF LRIICSHEHY VTLNLPCSLL TPPASPSPSV SSATSQSSGF STNVQDQKIA 1140 NMFELSVPFR QQHYLAGLVL TELAVILDPD AEGLFGLHKK VINMVHNLLS SHDSDPRYSD 1200 PQIKARVAML YLPLIGIIME TVPQLYDFTE THNQRGRPIC IATDDYESES GSMISQTVAM 1260 AIAGTSVPQL TRPGSFLLTS TSGRQHTTFS AESSRSLLIC LLWVLKNADE TVLQKWFTDL 1320 SVLQLNRLLD LLYLCVSCFE YKGKKVFERM NSLTFKKSKD MRAKLEEAIL GSIGARQEMV 1380 RRSRGQLGTY TIASPPERSP SGSAFGSQEN LRWRKDMTHW RQNTEKLDKS RAEIEHEALI 1440 DGNLATEANL IILDTLEIVV QTVSVTESKE SILGGVLKVL LHSMACNQSA VYLQHCFATQ 1500 RALVSKFPEL LFEEETEQCA DLCLRLLRHC SSSIGTIRSH ASASLYLLMR QNFEIGNNFA 1560 RVKMQVTMSL SSLVGTSQNF NEEFLRRSLK TILTYAEEDL ELRETTFPDQ VQDLVFNLHM 1620 ILSDTVKMKE HQEDPEMLID LMYRIAKGYQ TSPDLRLTWL QNMAGKHSER SNHAEAAQCL 1680 VHSAALVAEY LSMLEDRKYL PVGCVTFQNI SSNVLEESAV SDDVVSPDEE GICSGKYFTE 1740 SGLVGLLEQA AASFSMAGMY EAVNEVYKVL IPIHEANRDA KKLSTIHGKL QEAFSKIVHQ 1800 STGWERMFGT YFRVGFYGTK FGDLDEQEFV YKEPAITKLA EISHRLEGFY GERFGEDVVE 1860 VIKDSNPVDK CKLDPNKAYI QITYVEPYFD TYEMKDRITY FDKNYNLRRF MYCTPFTLDG 1920 RAHGELHEQF KRKTILTTSH AFPYIKTRVN VTHKEEIILT PIEVAIEDMQ KKTQELAFAT 1980 HQDPADPKML QMVLQGSVGT TVNQGPLEVA QVFLSEIPSD PKLFRHHNKL RLCFKDFTKR 2040 CEDALRKNKS LIGPDQKEYQ RELERNYHRL KEALQPLINR KIPQLYKAVL PVTCHRDSFS 2100 RMSLRKMDL 2109 |
Gene Ontology | GO:0030424; C:axon; TAS:BHF-UCL. GO:0045178; C:basal part of cell; TAS:BHF-UCL. GO:0030426; C:growth cone; TAS:BHF-UCL. GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. GO:0048365; F:Rac GTPase binding; IDA:BHF-UCL. GO:0032863; P:activation of Rac GTPase activity; IDA:BHF-UCL. GO:0007409; P:axonogenesis; IMP:BHF-UCL. GO:0045200; P:establishment of neuroblast polarity; IMP:BHF-UCL. GO:0000226; P:microtubule cytoskeleton organization; IMP:BHF-UCL. GO:0043473; P:pigmentation; IEA:Compara. GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:BHF-UCL. GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
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