UniProt Accession

 RCC2_MOUSE; Q8BK67; A2AWQ3; Q6ZPQ0 

Genbank Protein ID

 AK076040; AL954710; BC086666; AK129370 

Genbank Nucleotide ID

 BAC36140.1; CAM19332.1; AAH86666.1; BAC98180.1 

Protein Name

 Protein RCC2 

Protein Synonyms/Alias

  

Gene Name

 Rcc2 

Gene Synonyms/Alias

 Kiaa1470 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
291	LGHNSDGKFIARAQR	acetylation	[1, 2, 3]
316	RVAIFIEKTKDGQIL	acetylation	[1]
318	AIFIEKTKDGQILPV	acetylation	[3]
375	EMVPRLVKLFDFPGR	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1 (By similarity). 

Sequence Annotation

 REPEAT 101 163 RCC1 1.
 REPEAT 166 217 RCC1 2.
 REPEAT 219 269 RCC1 3.
 REPEAT 271 345 RCC1 4.
 REPEAT 346 399 RCC1 5.
 REPEAT 401 445 RCC1 6.
 REPEAT 446 499 RCC1 7.
 MOD_RES 14 14 Phosphoserine (By similarity).
 MOD_RES 41 41 Phosphoserine (By similarity).
 MOD_RES 42 42 Phosphoserine (By similarity).
 MOD_RES 43 43 Phosphoserine (By similarity).
 MOD_RES 44 44 Phosphoserine (By similarity).
 MOD_RES 48 48 Phosphoserine (By similarity).
 MOD_RES 49 49 Phosphoserine (By similarity).
 MOD_RES 90 90 N6-acetyllysine (By similarity).
 MOD_RES 291 291 N6-acetyllysine (By similarity).
 MOD_RES 340 340 Phosphothreonine (By similarity).
 MOD_RES 345 345 Phosphoserine (By similarity).
 MOD_RES 375 375 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 520 AA 

Protein Sequence

Gene Ontology

 GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW. 

Interpro

 IPR009091; RCC1/BLIP-II.
 IPR000408; Reg_chr_condens. 

Pfam

 PF00415; RCC1 

SMART

  

PROSITE

 PS00625; RCC1_1
 PS00626; RCC1_2
 PS50012; RCC1_3 

PRINTS

 PR00633; RCCNDNSATION.