Tag | Content |
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CPLM ID | CPLM-021778 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cytoplasmic dynein 2 heavy chain 1 |
Protein Synonyms/Alias | Cytoplasmic dynein 2 heavy chain; Dynein cytoplasmic heavy chain 2; Dynein heavy chain isotype 1B; Dynein-like protein 4 |
Gene Name | Dync2h1 |
Gene Synonyms/Alias | Dhc1b; Dlp4; Dnch2; Dnchc2 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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1030 | ESHQLMIKDQIEVMK | ubiquitination | [1] |
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Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity). |
Sequence Annotation | NP_BIND 145 152 ATP (Potential). NP_BIND 1689 1696 ATP (Potential). NP_BIND 1979 1986 ATP (Potential). NP_BIND 2291 2298 ATP (Potential). NP_BIND 2655 2662 ATP (Potential). REGION 1 1650 Stem (By similarity). REGION 1651 1875 AAA 1 (By similarity). REGION 1941 2161 AAA 2 (By similarity). REGION 2249 2505 AAA 3 (By similarity). REGION 2617 2862 AAA 4 (By similarity). REGION 2880 3168 Stalk (By similarity). REGION 3243 3472 AAA 5 (By similarity). REGION 3689 3904 AAA 6 (By similarity). |
Keyword | ATP-binding; Cell membrane; Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Dynein; Membrane; Microtubule; Motor protein; Nucleotide-binding; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 4306 AA |
Protein Sequence | MAGSLSDVRK LFLFTTTQNY FGLRPELWDQ TPLSNCPEVN NFLDDGNQML LRVQRSDAGL 60 AFSNTIDFDD TKDKVLVFFK LRPEVITDGN LHTNILVSSM LESPINSLYQ AVRQVFAPML 120 LKDQEWSRNF DPKLQNLLSE LEAGLGVVLR KSDTNLPKLK LKEDDTRGIL TPSDEFQFWI 180 EQAHRGSKQI SKERASYFKE LFETIAREFY NLDSLSLLEV VDLVETTRDV VDDVWRQAEH 240 DHYPESRMLH LLDVIGGSFG RFVQKKLGSL KLWEDPYYLV KENLKAGISI CEQWVIVCSH 300 LTGQVWQRYV PHPWKSEKYF PETLDRLGKR LEEVLAIRTI HEKLLYFLPA SEERIVCLSR 360 VFEPFTGVNP VQYNPYTEPL WKAAVSQYEK IIAPAEQKIA GKLKNYISEI QDSPQQLLQA 420 FLKYKELVKR PTISKELMLE RETLLARLGD SAKDFRLDFE NRCRGIPGDA SGPLSGKNLS 480 EVVNNIVWVR QLELKVDDTI KIAEALLSDL SGFRSFHRSA EDLLDQFKLY EQEQFDDWSR 540 EVQSGLSDSR SGLCIEANSR IMELDPNDGA LKVHYSDRLV ILLREVRQLS ALGFVIPAKI 600 QQVANVAQKF CKQAIILKQV AHFYNSIDQQ MIQSQRPMML QSALAFEQII KNSKAGSGGK 660 SQITWDNPKE LEGYIQKLQN AAERLATENR RLRKWHITFC EKVVILMNID LLRQQQRWKD 720 GLQELRTGLA SVAAQGFQPS DMRAWRQHWN HQLYKALEHQ YQMGLEALNE NLPEINVDLT 780 YKQGRLQFRP PFEEIRAKYY REMKRFIGIP NQFKGVGGAG DESIFSVMID RNASGFLTIY 840 SKAEDLFRRL SAVLHQHKEW VVIGQVDMEA LVEKNLSTVH DWEKNFKALK IKGKEVERLP 900 SAVKVDCLNI NCSPVKTVID DLIQKLFDLL VLSLKKSIQT HIHEIDTFVT EAMKVLTVIP 960 QSVEEIGDTN LQYSNLQDRR PEILPLFQEA EDKNRLLRTV AGGGVETVSN LRAKWDKFEL 1020 MMESHQLMIK DQIEVMKGNV KSRLQIYYQE LDKFKARWDQ LKPGDDIIET GQQNTMDQSA 1080 KSIKEKKIEF DDLEVIRKKL VDDCHHFGLE ESNFSLAYSI SKDIESCAQI WALYEEFQQG 1140 LQEMAKEDWI TYRTKIYIFE EFLINWHERL RKVEEHSVMT VKLQSEVDRY KIIIPILKYV 1200 RGEHLSPDHW LDLFRLLGLP RGTSLEKLLF GDLLRVADTI VEKASDLKDL NSRAQGEVTI 1260 REALRELDLW GVGAVFSLID YEDSQNRTIK LIKDWKDIVN QVGDNRCLLQ SLKDSPYYKG 1320 FEDKVSIWER KLAQLDEYLQ NLNHIQRKWV YLEPIFGRGA LPKEQTRFNK VDEDFRSIMM 1380 DIRKDSRVTT LTTHAGIRNT LLTILDQLQR CQKSLNEFLE EKRSAFPRFY FIGDDDLLEI 1440 LGQSTNPSVI QSHLKKLFAG INSVCFDEES KHITAMRSLE GEVVPFKSKV LLSNNVEAWL 1500 NDLALEMKQT LKQLLKECVT AGRSSQGAID PSLFPSQILC LAEQIKFTED VEDAIRDHSL 1560 HQIEAQLAAK LERYTSVDTS SEDPGNSESG ILELKLKTLI LDIIHNIDIV KQLNQAQVHT 1620 TDDWAWKKQV RFYMKSDHTC YVQMVDSELQ YTYEYQGNAP KLVYTPLTDK CYLTLTQAMK 1680 MGLGGNPYGP AGTGKTESVK ALGGLLGRQV LVFNCDEGID VKSMGRIFVG LVKCGAWGCF 1740 DEFNRLEEAV LSAVSMQIQT IQDALKNHRS VCELLGKEVE VNANSGIFIT MNPAGKGYGG 1800 RQKLPDNLKQ LFRPVAMSRP DNDLIAEVIL YSEGFKDAKE LGRKLVAIFN LSRELLTPQQ 1860 HYDWGLRALK TVLRGSGNLL RQLKKSGTKQ DVNENHIVVQ ALRLNTMSKF TFADCTRFDA 1920 LIKDVFPGID FKEVEYNELS SALKQVFEEA NYEVIPNQMK KALELYEQLR QRTGVVIVGP 1980 SGAGKSTLWR MLRAALCKIG KVVKQYTMNP KAMPRHQLLG HIDMDTREWS DGVLTNSARQ 2040 VVREPQDVSS WIICDGDIDP EWIESLNSVL DDNRLLTMPS GERIQFGPNV NFVFETHDLS 2100 CASPATISRM GMIFLSDEET DLNSLIKSWL RNQPVEYRSN LENWIGDYFS KALQWVLKQN 2160 DYVVETSLVG TVMNGLSHLH GCKYHDQFII NLIRGLGGNL NMKSRLEFTK EVFNWARETP 2220 PDSHRPMDTY FDCDRGQLAS YVLKKPESLT ADDFSSGHSL PVIQTPDMQR GLDYFKPWLS 2280 SETKQPFILV GPEGCGKGML LRYAFSQLRS TEIATIHCSA QTTSRHLLQK LSQTCMVIST 2340 NTGRVYRPKD CERLVLYLKD INLPKLDKWG TSTLVAFLQQ VLTYQGFYDE NLEWVGLENI 2400 QIVASMSAGG RLGRHKLTTR FTSIVRLCAV DYPEREQLQT IYGAYLEAVL HKNLKNHSIW 2460 GSSSKIYLLA GSMVQVYEQV RAKFTVDDYS HYFFTPCILT QWVLGLFRYD LEGGSSNHPL 2520 DYVLEVVAYE ARRLFRDKIV GVKELHLFDN ILTSVLQGDW GSDILDNMAD SFYVTWGAQH 2580 ISGAKIAPGQ PLPPHGKPLG KLSSADLKDV IKKGLIHYGR DNQNLDILLF QEVLEYMSRI 2640 DRVLSFPGGS LLLAGRSGVG RRTVTSLVSH MHGAVLFSPK ISRGYEPKQF RTDLKHVLHL 2700 AGIEAQQVVL LLEDYQFVHP TFLEMINSLL SSGEVPGLYT LEELEPLLLP LKDQASQDGF 2760 FGPVFNYFTY RIQQNLHIVL IMDSANLNFI INCESNPALH KKCRVLWMEG WSDSSMKKIP 2820 EMLFSEADIE EKYEKKRKDE KKKSSVDPDF IKSFLLIHES CKAYGATPSR YMTFLRVYSA 2880 ISSSKRKELL KRQSHLQAGV SKLNEAKALV DELNRKAGEQ SILLRIKQDE ADSALQEITV 2940 SMQDASEQKT ELERLKHRIA EEVVKIEERK SKIDDELKEV QPLVNEAKLA VGNIRPESLS 3000 EIRSLRMPPD VIRDILEGVL RLMGIFDTSW VSMKSFLAKR GVREDIATFD ARNIPKEIRE 3060 SVEELLFKNK ASFDPKNAKR ASTAAAPLAA WVKANVQYSH VLERIQPLET EQSGLELNLK 3120 KTEDRKRKLE DLLNSVGQKV SELKEKFQSR TSEAAKLEAE VSKAQETIKA AEVLISQLDR 3180 EHRRWNAQVA EIAEELATLP KRAQLAAAFI TYLSAAPEGL RKNCLEEWTK AAGLEKFDLR 3240 RFLCTESEQL IWKSEGLPSD DLSIENALVI LQSRVCPFLI DPSSQATEWL KTHLKDSHLE 3300 VINQQDSNFI TALELAVRFG KTLIIQEMDG VEPVLYPLLR RDLVAQGPRY VVQIGDKIID 3360 YNEDFRLFLS TRNPNPFIPP DAASIVTEVN FTTTRSGLRG QLLALTIQHE KPDLEEQKTK 3420 LLQQEEDKKI QLARLEESLL ETLATSQGNI LENKDLIESL NQTKASSALI QDSLKESYKL 3480 QISLDRERDA YLPLAESASK MYFIISDLSK INNMYRFSLA SFLRLFQRAL QNKQDSESTE 3540 QRIQCLVNSL KHMVYEYICR CLFKADQLMF ALHFVRGMHP EFFQENEWDT FTGVVVGDML 3600 RKADSQQRIR DQLPSWIDQE RSWAVATLKI SLPGLYQTLC FEDGTLWRTY YHHSMCEQEF 3660 PSILAKKVSL FQQVLVVQAL RPDRLQSAMA LFACKALGLK ELSPLPLNLK RLYKETLEIE 3720 PILIIISPGA DPSQELQELA NAERSSERYH QVAMGQGQAD LAIQMLKECA RNGDWLCLKN 3780 LHLVVSWLPV LEKELNTLQP KESFRLWLTA EVHPNFTPIL LQSSLKITYE SPPGLKKNLM 3840 RTYESWTPEQ ISKKDNIHRA HALFSLAWFH AACQERRNFI PQGWTKFYEF SLSDLRAGYH 3900 VIDRLFDGSK DVQWEFVHGL LENSIYGGRI DNYFDLRVLQ SYLKQFFNSS IIDVLNQRNK 3960 KSIFPYSISL PDSCSILDYR AVIEKLPEDD KPSFFGLPAN IARSSQRMTS SQVISQLRIL 4020 GRSVTAGCKF DREIWSNELS PVLNLWKKLN QNSNLIHQKV SPPNDRQGSP ILSFIILEQF 4080 NAIRLVQSVH QSLAALSKVI RGTTLLSSEV QKLASALLNQ KCPLTWQSKW EGPEDPLQYL 4140 RGLVARTLAI QNWVEKAEKQ ALLADTLDLS ELFHPDTFLN ALRQETARAT GCSVDSLKFV 4200 ASWKGRLQEA KLQIKISGLL LEGCSFDGSR LSENQHDSPS VSSVLPCYMG WTPQGSYGPY 4260 SPDECISLPV YTSAERDCVV TNIDVPCGGN QDQWIQCGAA LFLKNQ 4306 |
Gene Ontology | GO:0035085; C:cilium axoneme; IEA:UniProtKB-SubCell. GO:0030286; C:dynein complex; IEA:UniProtKB-KW. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0016887; F:ATPase activity; IEA:InterPro. GO:0003777; F:microtubule motor activity; IEA:InterPro. GO:0006200; P:ATP catabolic process; IEA:GOC. GO:0030031; P:cell projection assembly; IEA:InterPro. GO:0001539; P:ciliary or flagellar motility; IEA:InterPro. GO:0007018; P:microtubule-based movement; IEA:InterPro. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |