CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041565
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphorylase 
Protein Synonyms/Alias
  
Gene Name
 Pygb 
Gene Synonyms/Alias
 rCG_37246 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
3*****MAKPLTDSERacetylation[1]
3*****MAKPLTDSERubiquitination[2]
42HLHFTLVKDRNVATPacetylation[1]
254AKAPNDFKLKDFNVGacetylation[1]
256APNDFKLKDFNVGDYacetylation[1]
290NDNFFEGKELRLKQEacetylation[1]
295EGKELRLKQEYFVVAacetylation[1]
316IRRFKSSKFGCRDPVacetylation[1]
364VEKVDWDKAWEITKKacetylation[1]
370DKAWEITKKTCAYTNacetylation[1]
483EPEKFQNKTNGITPRubiquitination[2]
520LTDLSQLKKLLSLVDacetylation[1]
552KFSAQLEKEYKVKINacetylation[1]
555AQLEKEYKVKINPASacetylation[1]
575VKRIHEYKRQLLNCLacetylation[1]
618APGYHMAKMIIKLVTacetylation[1]
725DVEALDQKGYNAREFacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). 
Sequence Annotation
  
Keyword
 Carbohydrate metabolism; Complete proteome; Glycosyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 843 AA 
Protein Sequence
MAKPLTDSER QKQISVRGIA GLGDVAEVRK SFNRHLHFTL VKDRNVATPR DYFFALAHTV 60
RDHLVGRWIR TQQHYYERDP KRIYYLSLEF YMGRTLQNTM VNLGLQTACD EATYQLGLDL 120
EELEEIEEDA GLGNGGLGRL AACFLDSMAT LGLAAYGYGI RYEFGIFNQK IVNGWQVEEA 180
DDWLRYGNPW EKARPEYMLP VHFYGRVEHT PNGVLWLDTQ VVLAMPYDTP VPGYKNNTVN 240
TMRLWSAKAP NDFKLKDFNV GDYIEAVLDR NLAENISRVL YPNDNFFEGK ELRLKQEYFV 300
VAATLQDIIR RFKSSKFGCR DPVRTCFETF PDKVAIQLND THPALSIPEL MRILVDVEKV 360
DWDKAWEITK KTCAYTNHTV LPEALERWPV SMFEKLLPRH LEIIYAINQR HLDHVAALFP 420
GDVDRLRRMS VIEEGDCKRI NMAHLCVIGS HAVNGVARIH SEIVKQSVFK DFYELEPEKF 480
QNKTNGITPR RWLLLCNPGL AEIIVERIGE GFLTDLSQLK KLLSLVDDEA FIRDVAKVKQ 540
ENKLKFSAQL EKEYKVKINP ASMFDVHVKR IHEYKRQLLN CLHIITLYNR IKKDPTKTFV 600
PRTVMIGGKA APGYHMAKMI IKLVTSIGDV VNHDPVVGDR LRVIFLENYR VSLAEKVIPA 660
ADLSQQISTA GTEASGTGNM KFMLNGALTI GTMDGANVEM AEEAGEENLF IFGMRVEDVE 720
ALDQKGYNAR EFYERLPELR QAVDQISSGF FSPKDPDCFK DVVNMLMYHD RFKVFADYEA 780
YIQCQAQVDH LYRNPKDWTK KVIRNIACSG KFSSDRTITE YAREIWGVEP SDLQIPPPNL 840
PKD 843 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0008184; F:glycogen phosphorylase activity; IEA:InterPro.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW. 
Interpro
 IPR011833; Glycg_phsphrylas.
 IPR000811; Glyco_trans_35. 
Pfam
 PF00343; Phosphorylase 
SMART
  
PROSITE
 PS00102; PHOSPHORYLASE 
PRINTS