CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036746
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DNA topoisomerase I, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 TOP1MT 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
222VALYFIDKLALRAGNubiquitination[1]
231ALRAGNEKEDGEAADubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 376 AA 
Protein Sequence
MLDHEYTTKE VFRKNFFNDW RKEMAVEERE VIKSLDKCDF TEIHRYFVDK AAARKVLSRE 60
EKQKLKEEAE KLQQEFGYCI LDGHQEKIGN FKIEPPGLFR GRGDHPKMGM LKRRITPEDV 120
VINCSRDSKI PEPPAGHQWK EVRSDNTVTW LAAWTESVQN SIKYIMLNPC SKLKGETAWQ 180
KFETARRLRG FVDEIRSQYR ADWKSREMKT RQRAVALYFI DKLALRAGNE KEDGEAADTV 240
GCCSLRVEHV QLHPEADGCQ HVVEFDFLGK DCIRYYNRVP VEKPVYKNLQ LFMENKDPRD 300
DLFDRLTVSW DGPAKPRNYR DHFPPQTTSL NKHLQELMDG LTAKVFRTYN ASITLQEQLR 360
ALTRAEDSIA AKILSY 376 
Gene Ontology
 GO:0005694; C:chromosome; IEA:InterPro.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0003917; F:DNA topoisomerase type I activity; IEA:InterPro.
 GO:0003918; F:DNA topoisomerase type II (ATP-hydrolyzing) activity; IEA:InterPro.
 GO:0006265; P:DNA topological change; IEA:InterPro. 
Interpro
 IPR011010; DNA_brk_join_enz.
 IPR013034; DNA_topo_domain1.
 IPR001631; TopoI.
 IPR014711; TopoI_cat_a-hlx-sub_euk.
 IPR013500; TopoI_cat_euk.
 IPR008336; TopoI_DNA-bd_euk.
 IPR013030; TopoI_DNA-bd_mixed-a/b_euk.
 IPR013499; TopoI_euk. 
Pfam
 PF01028; Topoisom_I
 PF02919; Topoisom_I_N 
SMART
 SM00435; TOPEUc 
PROSITE
  
PRINTS
 PR00416; EUTPISMRASEI.