UniProt Accession

 AROE_ECOLI; P15770; Q2M6U6 

Genbank Protein ID

 Y00710; U18997; U00096; AP009048 

Genbank Nucleotide ID

 CAA68700.1; AAA58078.1; AAC76306.1; BAE78010.1 

Protein Name

 Shikimate dehydrogenase 

Protein Synonyms/Alias

  

Gene Name

 aroE 

Gene Synonyms/Alias

 b3281; JW3242 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
65	ANVTVPFKEEAFARA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

  

Sequence Annotation

 NP_BIND 126 130 NAD.
 NP_BIND 149 154 NAD.
 NP_BIND 237 241 NAD.
 ACT_SITE 65 65 Proton acceptor (Potential).
 BINDING 102 102 Substrate (By similarity).
 BINDING 189 189 NAD; via amide nitrogen.
 BINDING 213 213 NAD; via carbonyl oxygen.  

Keyword

 3D-structure; Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Direct protein sequencing; NADP; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 272 AA 

Protein Sequence

Gene Ontology

 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0004764; F:shikimate 3-dehydrogenase (NADP+) activity; IEA:HAMAP.
 GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:HAMAP.
 GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0019632; P:shikimate metabolic process; IEA:InterPro. 

Interpro

 IPR016040; NAD(P)-bd_dom.
 IPR011342; Shikimate_DH.
 IPR013708; Shikimate_DH-bd_N.
 IPR022893; Shikimate_quinate_DH.
 IPR006151; Shikm_DH/Glu-tRNA_Rdtase. 

Pfam

 PF01488; Shikimate_DH
 PF08501; Shikimate_dh_N 

SMART

  

PROSITE

  

PRINTS