UniProt Accession

 ARC_MOUSE; Q9WV31; Q9ES15 

Genbank Protein ID

 AF177701; AF162777; AK157822; AK170446; BC023127; AF254662 

Genbank Nucleotide ID

 AAK91587.1; AAD43586.1; BAE34212.1; BAE41804.1; AAH23127.1; AAG10254.1 

Protein Name

 Activity-regulated cytoskeleton-associated protein 

Protein Synonyms/Alias

 ARC/ARG3.1; mArc; Activity-regulated gene 3.1 protein homolog; Arg3.1 

Gene Name

 Arc 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
24	PRGGPAAKPNVILQI	ubiquitination	[1]
269	KNWVEFKKEFLQYSE	ubiquitination	[1]
293	RELELPQKQGEPLDQ	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (By similarity). Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors. 

Sequence Annotation

 REGION 89 100 Binds SH3GL1 or SH3GL3 (By similarity).
 REGION 195 214 Required for binding DNM2 (By  

Keyword

 Cell junction; Cell membrane; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Developmental protein; Endocytosis; Endosome; Membrane; Postsynaptic cell membrane; Reference proteome; Synapse. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 396 AA 

Protein Sequence

Gene Ontology

 GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; TAS:MGI.
 GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0003779; F:actin binding; TAS:MGI.
 GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
 GO:0016477; P:cell migration; ISS:UniProtKB.
 GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0007492; P:endoderm development; IMP:MGI.
 GO:0007612; P:learning; IEA:Compara.
 GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB.
 GO:0048168; P:regulation of neuronal synaptic plasticity; IEA:Compara. 

Interpro

 IPR023263; Activity-reg_cytoskelet-assoc. 

Pfam

  

SMART

  

PROSITE

  

PRINTS

 PR02027; ARCARG31.