CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010010
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Signal recognition particle protein 
Protein Synonyms/Alias
 Fifty-four homolog 
Gene Name
 ffh 
Gene Synonyms/Alias
 MPN_061; MP093 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
175QTTKEAVKTFKESGCacetylation[1]
276KLMGTSEKLTGLEQFacetylation[1]
311KAEEVFDKQSLTKTVacetylation[1]
413RKMDELNKLMKEWSKacetylation[1]
416DELNKLMKEWSKLQTacetylation[1]
420KLMKEWSKLQTKTAEacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity). 
Sequence Annotation
 NP_BIND 106 113 GTP (By similarity).
 NP_BIND 188 192 GTP (By similarity).
 NP_BIND 246 249 GTP (By similarity).  
Keyword
 Complete proteome; Cytoplasm; GTP-binding; Nucleotide-binding; Reference proteome; Ribonucleoprotein; RNA-binding; Signal recognition particle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 450 AA 
Protein Sequence
MFKSMISSIV MRSMQKKINA QTISETDVQA VLKEIRIALL DADVNLLVVK NFIKAIREQT 60
VGQTVEPGQD LQKWLLKVIK QELINILSQP NQEITSKRPL KVMVVGLQGS GKTTTCGKLA 120
VWLKKQFQQK AMLVALDIYR PAAIDQLATL AEQTESVFFA KGTQAPDQTT KEAVKTFKES 180
GCQAIICDTA GRLQTNQELM DELVAIKNEL HPDEILMVVD GLSGQEIINV AKEFHNRLKL 240
TGFIITKLDS DARAGAALSL TSLLEVPIKL MGTSEKLTGL EQFHPERIAS RILGLGDVMT 300
LVEKAEEVFD KQSLTKTVSK MFLGKMDLED LLLYMEQMNQ MGSVSSIVKM LPGNLTVSDD 360
HVESIEAKVK LWKVLINSMT REERRHPKLI NRDPSRKQRI IKGSGRKMDE LNKLMKEWSK 420
LQTKTAEMGR MLKGGKNPFS GFGGLGGLGF 450 
Gene Ontology
 GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-KW.
 GO:0008312; F:7S RNA binding; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:HAMAP.
 GO:0003924; F:GTPase activity; IEA:HAMAP.
 GO:0006184; P:GTP catabolic process; IEA:GOC.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR027417; P-loop_NTPase.
 IPR013822; Signal_recog_particl_SRP54_hlx.
 IPR004125; Signal_recog_particle_SRP54_M.
 IPR022941; SRP54.
 IPR000897; SRP54_GTPase_dom.
 IPR004780; SRP_Ffh. 
Pfam
 PF00448; SRP54
 PF02881; SRP54_N
 PF02978; SRP_SPB 
SMART
 SM00382; AAA
 SM00962; SRP54
 SM00963; SRP54_N 
PROSITE
 PS00300; SRP54 
PRINTS