| Tag | Content |
|---|
| CPLM ID | CPLM-007728 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | N-acetylmannosamine kinase |
Protein Synonyms/Alias | ManNAc kinase; N-acetyl-D-mannosamine kinase |
Gene Name | nanK |
Gene Synonyms/Alias | yhcI; b3222; JW5538 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 290 | ALLAQGEKL****** | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. Has also low level glucokinase activity in vitro. |
Sequence Annotation | NP_BIND 5 12 ATP (Potential).
NP_BIND 132 139 ATP (Potential).
METAL 156 156 Zinc.
METAL 166 166 Zinc.
METAL 168 168 Zinc.
METAL 173 173 Zinc. |
Keyword | 3D-structure; ATP-binding; Carbohydrate metabolism; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Transferase; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 291 AA |
Protein Sequence | MTTLAIDIGG TKLAAALIGA DGQIRDRREL PTPASQTPEA LRDALSALVS PLQAHAQRVA 60
IASTGIIRDG SLLALNPHNL GGLLHFPLVK TLEQLTNLPT IAINDAQAAA WAEFQALDGD 120
ITDMVFITVS TGVGGGVVSG CKLLTGPGGL AGHIGHTLAD PHGPVCGCGR TGCVEAIASG 180
RGIAAAAQGE LAGADAKTIF TRAGQGDEQA QQLIHRSART LARLIADIKA TTDCQCVVVG 240
GSVGLAEGYL ALVETYLAQE PAAFHVDLLA AHYRHDAGLL GAALLAQGEK L 291 |
Gene Ontology | GO:0005524; F:ATP binding; IEA:HAMAP. GO:0009384; F:N-acylmannosamine kinase activity; IDA:EcoCyc. GO:0008270; F:zinc ion binding; IEA:HAMAP. GO:0006051; P:N-acetylmannosamine metabolic process; IEA:HAMAP. GO:0019262; P:N-acetylneuraminate catabolic process; IDA:EcoCyc. GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki. |
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