CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039755
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nik-related protein kinase 
Protein Synonyms/Alias
  
Gene Name
 NRK 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
819SLLEQAQKPIDIRQRmethylation[1]
Reference
 [1] A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation.
 Moore KE, Carlson SM, Camp ND, Cheung P, James RG, Chua KF, Wolf-Yadlin A, Gozani O.
 Mol Cell. 2013 May 9;50(3):444-56. [PMID: 23583077
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1583 AA 
Protein Sequence
MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGAF TAVKVMNARK 60
TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY SFHKNIVSFY GAFFKLSPPG 120
QRHQLWMVME LCAAGSVTDV VRMTSNQSLK EDWIAYICRE ILQGLAHLHA HRVIHRDIKG 180
QNVLLTHNAE VKLVDFGVSA QVSRTNGRRN SFIGTPYWMA PEVIDCDEDP RRSYDYRSDV 240
WSVGITAIEM AEGAPPLCNL QPLEALFVIL RESAPTVKSS GWSRKFHNFM EKCTIKNFLF 300
RPTSANMLQH PFVRDIKNER HVVESLTRHL TGIIKKRQKK KGIPLIFERE EAIKEQYTVR 360
RFRGPSCTHE LLRLPTSSRC RPLRVLHGEP SQPRWLPDRE EPQVQALQQL QGAARVFMPL 420
QALDSAPKPL KGQAQAPQRL QGAARVFMPL QAQVKAKASK PLQMQIKAPP RLRRAARVLM 480
PLQAQVRAPR LLQVQSQVSK KQQAQTQTSE PQDLDQVPEE FQGQDQVPEQ QRQGQAPEQQ 540
QRHNQVPEQE LEQNQAPEQP EVQEQAAEPA QAETEAEEPE SLRVNAQVFL PLLSQDHHVL 600
LPLHLDTQVL IPVEGQTEGS PQAQAWTLEP PQAIGSVQAL IEGLSRDLLR APNSNNSKPL 660
GPLQTLMENL SSNRFYSQPE QAREKKSKVS TLRQALAKRL SPKRFRAKSS WRPEKLELSD 720
LEARRQRRQR RWEDIFNQHE EELRQVDKDK EDESSDNDEV FHSIQAEVQI EPLKPYISNP 780
KKIEVQERSP SVPNNQDHAH HVKFSSSVPQ RSLLEQAQKP IDIRQRSSQN RQNWLAASES 840
SSEEESPVTG RRSQSSPPYS TIDQKLLVDI HVPDGFKVGK ISPPVYLTNE WVGYNALSEI 900
FRNDWLTPAP VIQPPEEDGD YVELYDASAD TDGDDDDESN DTFEDTYDHA NGNDDLDNQV 960
DQANDVCKDH DDDNNKFVDD VNNNYYEAPS CPRASYGRDG SCKQDGYDGS RGKEEAYRGY 1020
GSHTANRSHG GSAASEDNAA IGDQEEHAAN IGSERRGSEG DGGKGVVRTS EESGALGLNG 1080
EENCSETDGP GLKRPASQDF EYLQEEPGGG NEASNAIDSG AAPSAPDHES DNKDISESST 1140
QSDFSANHSS PSKGSGMSAD ANFASAILYA GFVEVPEESP KQPSEVNVNP LYVSPACKKP 1200
LIHMYEKEFT SEICCGSLWG VNLLLGTRSN LYLMDRSGKA DITKLIRRRP FRQIQVLEPL 1260
NLLITISGHK NRLRVYHLTW LRNKILNNDP ESKRRQEEML KTEEACKAID KLTGCEHFSV 1320
LQHEETTYIA IALKSSIHLY AWAPKSFDES TAIKVCIDQS ADSEGDYMSY QAYIRILAKI 1380
QAADPVNRFK RPDELLHLLK LKVFPTLDHK PVTVDLAIGS EKRLKIFFSS ADGYHLIDAE 1440
SEVMSDVTLP KNPLEIIIPQ NIIILPDCLG IGMMLTFNAE ALSVEANEQL FKKILEMWKD 1500
IPSSIAFECT QRTTGWGQKA IEVRSLQSRV LESELKRRSI KKLRFLCTRG DKLFFTSTLR 1560
NHHSRVYFMT LGKLEELQSN YDV 1583 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
 GO:0005083; F:small GTPase regulator activity; IEA:InterPro.
 GO:0007256; P:activation of JNKK activity; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0007567; P:parturition; IEA:Compara.
 GO:0060721; P:regulation of spongiotrophoblast cell proliferation; IEA:Compara. 
Interpro
 IPR001180; Citron.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00780; CNH
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS50219; CNH
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS