| Tag | Content |
|---|
| CPLM ID | CPLM-006710 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Amiloride-sensitive sodium channel subunit alpha |
Protein Synonyms/Alias | Alpha-NaCH; Epithelial Na(+) channel subunit alpha; Alpha-ENaC; ENaCA; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA |
Gene Name | SCNN1A |
Gene Synonyms/Alias | SCNN1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 203 | PYRYPEIKEELEELD | ubiquitination | [1] | | 279 | NNPQVDWKDWKIGFQ | ubiquitination | [1] | | 588 | AKVNIFFKELNYKTN | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. |
Sequence Annotation | CARBOHYD 232 232 N-linked (GlcNAc...) (Potential).
CARBOHYD 293 293 N-linked (GlcNAc...) (Potential).
CARBOHYD 312 312 N-linked (GlcNAc...) (Potential).
CARBOHYD 397 397 N-linked (GlcNAc...) (Potential).
CARBOHYD 511 511 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Disease mutation; Glycoprotein; Ion channel; Ion transport; Membrane; Polymorphism; Reference proteome; Sensory transduction; Sodium; Sodium channel; Sodium transport; Taste; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 669 AA |
Protein Sequence | MGMARGSLTR VPGVMGEGTQ GPELSLDPDP CSPQSTPGLM KGNKLEEQDP RPLQPIPGLM 60
EGNKLEEQDS SPPQSTPGLM KGNKREEQGL GPEPAAPQQP TAEEEALIEF HRSYRELFEF 120
FCNNTTIHGA IRLVCSQHNR MKTAFWAVLW LCTFGMMYWQ FGLLFGEYFS YPVSLNINLN 180
SDKLVFPAVT ICTLNPYRYP EIKEELEELD RITEQTLFDL YKYSSFTTLV AGSRSRRDLR 240
GTLPHPLQRL RVPPPPHGAR RARSVASSLR DNNPQVDWKD WKIGFQLCNQ NKSDCFYQTY 300
SSGVDAVREW YRFHYINILS RLPETLPSLE EDTLGNFIFA CRFNQVSCNQ ANYSHFHHPM 360
YGNCYTFNDK NNSNLWMSSM PGINNGLSLM LRAEQNDFIP LLSTVTGARV MVHGQDEPAF 420
MDDGGFNLRP GVETSISMRK ETLDRLGGDY GDCTKNGSDV PVENLYPSKY TQQVCIHSCF 480
QESMIKECGC AYIFYPRPQN VEYCDYRKHS SWGYCYYKLQ VDFSSDHLGC FTKCRKPCSV 540
TSYQLSAGYS RWPSVTSQEW VFQMLSRQNN YTVNNKRNGV AKVNIFFKEL NYKTNSESPS 600
VTMVTLLSNL GSQWSLWFGS SVLSVVEMAE LVFDLLVIMF LMLLRRFRSR YWSPGRGGRG 660
AQEVASTLAS SPPSHFCPHP MSLSLSQPGP APSPALTAPP PAYATLGPRP SPGGSAGASS 720
STCPLGGP 728 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell. GO:0030864; C:cortical actin cytoskeleton; IEA:Compara. GO:0009897; C:external side of plasma membrane; IEA:Compara. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0034706; C:sodium channel complex; IEA:Compara. GO:0015280; F:ligand-gated sodium channel activity; IEA:Compara. GO:0007588; P:excretion; TAS:ProtInc. GO:0034220; P:ion transmembrane transport; TAS:Reactome. GO:0050896; P:response to stimulus; IEA:UniProtKB-KW. GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW. GO:0006814; P:sodium ion transport; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |