CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013352
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GRIP1-associated protein 1 
Protein Synonyms/Alias
 GRASP-1 
Gene Name
 GRIPAP1 
Gene Synonyms/Alias
 KIAA1167 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
149AENTALQKNVAALQEubiquitination[1, 2]
249FCRLQTEKETLFNDSubiquitination[1, 2]
259LFNDSRNKIEELQQRubiquitination[1, 2]
640QDILTNSKSRSGLEEubiquitination[3]
722LAETQQEKWMLEEKVubiquitination[3]
728EKWMLEEKVKHLEVSubiquitination[3]
746MAEDLCRKSAIIETYubiquitination[3]
782SVLRDLVKPGDENLRubiquitination[3]
794NLREMNKKLQNMLEEubiquitination[3]
825QEIVRLSKECVGPPDubiquitination[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 MOD_RES 655 655 Phosphoserine.
 MOD_RES 666 666 Phosphoserine.
 MOD_RES 669 669 Phosphoserine (By similarity).
 MOD_RES 690 690 Phosphoserine.
 MOD_RES 692 692 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; Endosome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 841 AA 
Protein Sequence
MAQALSEEEF QRMQAQLLEL RTNNYQLSDE LRKNGVELTS LRQKVAYLDK EFSKAQKALS 60
KSKKAQEVEV LLSENEMLQA KLHSQEEDFR LQNSTLMAEF SKLCSQMEQL EQENQQLKEG 120
AAGAGVAQAG PLVDGELLRL QAENTALQKN VAALQERYGK EAGKFSAVSE GQGDPPGGPA 180
PTVLAPMPLA EVELKWEMEK EEKRLLWEQL QGLESSKQAE TSRLQEELAK LSEKLKKKQE 240
SFCRLQTEKE TLFNDSRNKI EELQQRKEAD HKAQLARTQK LQQELEAANQ SLAELRDQRQ 300
GERLEHAAAL RALQDQVSIQ SADAQEQVEG LLAENNALRT SLAALEQIQT AKTQELNMLR 360
EQTTGLAAEL QQQQAEYEDL MGQKDDLNSQ LQESLRANSR LLEQLQEIGQ EKEQLTQELQ 420
EARKSAEKRK AMLDELAMET LQEKSQHKEE LGAVRLRHEK EVLGVRARYE RELRELHEDK 480
KRQEEELRGQ IREEKARTRE LETLQQTVEE LQAQVHSMDG AKGWFERRLK EAEESLQQQQ 540
QEQEEALKQC REQHAAELKG KEEELQDVRD QLEQAQEERD CHLKTISSLK QEVKDTVDGQ 600
RILEKKGSAA LKDLKRQLHL ERKRADKLQE RLQDILTNSK SRSGLEELVL SEMNSPSRTQ 660
TGDSSSISSF SYREILREKE SSAVPARSLS SSPQAQPPRP AELSDEEVAE LFQRLAETQQ 720
EKWMLEEKVK HLEVSSASMA EDLCRKSAII ETYVMDSRID VSVAAGHTDR SGLGSVLRDL 780
VKPGDENLRE MNKKLQNMLE EQLTKNMHLH KDMEVLSQEI VRLSKECVGP PDPDLEPGET 840
S 841 
Gene Ontology
 GO:0005769; C:early endosome; IEA:UniProtKB-SubCell. 
Interpro
 IPR026204; GRIPAP1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS