CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040815
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transducin-like enhancer protein 3 
Protein Synonyms/Alias
  
Gene Name
 TLE3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
30AESCDRIKDEFQFLQubiquitination[1]
343GLRSMPGKPPGMDPIacetylation[2]
343GLRSMPGKPPGMDPIubiquitination[1, 3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 764 AA 
Protein Sequence
MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 60
YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 120
AIIGQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG ALGSQAHLTV 180
KDEKNHHELD HRERSSASNN SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS 240
DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLDKARSLK KDAPTSPASV ASSSSTPSSK 300
TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI ASALRTPISI 360
TSSYAAPFAM MSHHEMNGSL TSPGAYAGLH NIPPQMSAAA AAAAAAYGRS PMVGFDPHPP 420
MRATGLPSSL ASIPGGKPAY SFHVSADGQM QPVPFPHDAL AGPGIPRHAR QINTLSHGEV 480
VCAVTISNPT RHVYTGGKGC VKIWDISQPG SKSPISQLDC LNRDNYIRSC KLLPDGRTLI 540
VGGEASTLTI WDLASPTPRI KAELTSSAPA CYALAISPDA KVCFSCCSDG NIAVWDLHNQ 600
TLVRQFQGHT DGASCIDISH DGTKLWTGGL DNTVRSWDLR EGRQLQQHDF TSQIFSLGYC 660
PTGEWLAVGM ESSNVEVLHH TKPDKYQLHL HESCVLSLKF AYCGKWFVST GKDNLLNAWR 720
TPYGASIFQS KESSSVLSCD ISADDKYIVT GSGDKKATVY EVIY 764 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR005617; Groucho/TLE_N.
 IPR009146; Groucho_enhance.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF03920; TLE_N
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR01850; GROUCHOFAMLY.