UniProt Accession

 LAT_RAT; O70601 

Genbank Protein ID

 AJ001184 

Genbank Nucleotide ID

 CAA04577.1 

Protein Name

 Linker for activation of T-cells family member 1 

Protein Synonyms/Alias

 36 kDa phospho-tyrosine adapter protein; pp36; p36-38 

Gene Name

 Lat 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
53	YPRSILIKPPQITVP	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules (By similarity). 

Sequence Annotation

 REGION 136 139 Interaction with PLCG1 (By similarity).
 REGION 175 178 Interaction with GRB2, GRAP2 and PIK3R1
 REGION 195 198 Interaction with GRB2, GRAP2 and PIK3R1
 MOD_RES 41 41 Phosphoserine (By similarity).
 MOD_RES 44 44 Phosphoserine (By similarity).
 MOD_RES 87 87 Phosphoserine (By similarity).
 MOD_RES 104 104 Phosphoserine (By similarity).
 MOD_RES 109 109 Phosphoserine (By similarity).
 MOD_RES 175 175 Phosphotyrosine (By similarity).
 MOD_RES 199 199 Phosphoserine (By similarity).
 MOD_RES 215 215 Phosphoserine (By similarity).
 MOD_RES 234 234 Phosphotyrosine (By similarity).
 LIPID 27 27 S-palmitoyl cysteine (By similarity).
 LIPID 30 30 S-palmitoyl cysteine (By similarity).  

Keyword

 Adaptive immunity; Cell membrane; Complete proteome; Immunity; Lipoprotein; Mast cell degranulation; Membrane; Palmitate; Phosphoprotein; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 241 AA 

Protein Sequence

Gene Ontology

 GO:0001772; C:immunological synapse; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008180; C:signalosome; ISS:UniProtKB.
 GO:0010467; P:gene expression; IEA:Compara.
 GO:0006954; P:inflammatory response; IEA:Compara.
 GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
 GO:0007165; P:signal transduction; IEA:InterPro. 

Interpro

 IPR008359; Linker_for_activat_Tcells_prot. 

Pfam

  

SMART

  

PROSITE

  

PRINTS

 PR01781; LATPROTEIN.