| Tag | Content |
|---|
| CPLM ID | CPLM-011228 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transducin-like enhancer protein 3 |
Protein Synonyms/Alias | Enhancer of split groucho-like protein 3; ESG3 |
Gene Name | TLE3 |
Gene Synonyms/Alias | KIAA1547 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 494 | RHVYTGGKGCVKIWD | ubiquitination | [1] | | 708 | KWFVSTGKDNLLNAW | ubiquitination | [1] |
|
Reference | [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI. J Proteome Res. 2012 Feb 3;11(2):796-807. [ PMID: 22053931] |
Functional Description | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). |
Sequence Annotation | REPEAT 484 522 WD 1.
REPEAT 530 569 WD 2.
REPEAT 574 613 WD 3.
REPEAT 616 655 WD 4.
REPEAT 657 696 WD 5.
REPEAT 698 737 WD 6.
REPEAT 739 771 WD 7.
REGION 199 268 CCN domain.
MOTIF 225 228 Nuclear localization signal (Potential).
MOD_RES 203 203 Phosphoserine.
MOD_RES 207 207 Phosphoserine.
MOD_RES 217 217 Phosphoserine.
MOD_RES 240 240 Phosphoserine.
MOD_RES 245 245 Phosphoserine.
MOD_RES 259 259 Phosphothreonine.
MOD_RES 263 263 Phosphoserine.
MOD_RES 267 267 Phosphoserine.
MOD_RES 286 286 Phosphoserine.
MOD_RES 312 312 Phosphothreonine.
MOD_RES 317 317 Phosphoserine.
MOD_RES 319 319 Phosphothreonine.
MOD_RES 321 321 Phosphothreonine.
MOD_RES 328 328 Phosphothreonine.
MOD_RES 334 334 Phosphothreonine.
MOD_RES 413 413 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; WD repeat; Wnt signaling pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 772 AA |
Protein Sequence | MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 60
YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 120
AIIGQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG ALGSQAHLTV 180
KDEKNHHELD HRERESSANN SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS 240
DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLDKARSLK KDAPTSPASV ASSSSTPSSK 300
TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PASALRTPIS ITSSYAAPFA 360
MMSHHEMNGS LTSPGAYAGL HNIPPQMSAA AAAAAAAYGR SPMVSFGAVG FDPHPPMRAT 420
GLPSSLASIP GGKPAYSFHV SADGQMQPVP FPHDALAGPG IPRHARQINT LSHGEVVCAV 480
TISNPTRHVY TGGKGCVKIW DISQPGSKSP ISQLDCLNRD NYIRSCKLLP DGRTLIVGGE 540
ASTLTIWDLA SPTPRIKAEL TSSAPACYAL AISPDAKVCF SCCSDGNIAV WDLHNQTLVR 600
QFQGHTDGAS CIDISHDGTK LWTGGLDNTV RSWDLREGRQ LQQHDFTSQI FSLGYCPTGE 660
WLAVGMESSN VEVLHHTKPD KYQLHLHESC VLSLKFAYCG KWFVSTGKDN LLNAWRTPYG 720
ASIFQSKESS SVLSCDISAD DKYIVTGSGD KKATVYEVIY 760 |
Gene Ontology | GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0007219; P:Notch signaling pathway; TAS:Reactome. GO:0009887; P:organ morphogenesis; TAS:ProtInc. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |