UniProt Accession

 RPB7_MOUSE; P62488; P52433 

Genbank Protein ID

 AK010687; AK011627; AK013134; AK017473; BC005580; BC055278 

Genbank Nucleotide ID

 BAB27119.1; BAB27743.1; BAB28670.1; BAB30760.1; AAH05580.3; AAH55278.1 

Protein Name

 DNA-directed RNA polymerase II subunit RPB7 

Protein Synonyms/Alias

 RNA polymerase II subunit B7; DNA-directed RNA polymerase II subunit G 

Gene Name

 Polr2g 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
27	PNLLNTVKQKLFTEV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Binds RNA (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; DNA-directed RNA polymerase; Nucleotidyltransferase; Nucleus; Reference proteome; RNA-binding; Transcription; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 172 AA 

Protein Sequence

Gene Ontology

 GO:0005665; C:DNA-directed RNA polymerase II, core complex; ISS:UniProtKB.
 GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
 GO:0004672; F:protein kinase activity; IEA:Compara.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; ISS:UniProtKB. 

Interpro

 IPR012340; NA-bd_OB-fold.
 IPR003029; Rbsml_prot_S1_RNA-bd_dom.
 IPR022967; RNA-binding_domain_S1.
 IPR005576; RNA_pol_Rpb7_N. 

Pfam

 PF00575; S1
 PF03876; SHS2_Rpb7-N 

SMART

 SM00316; S1 

PROSITE

  

PRINTS