CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009759
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acetylornithine aminotransferase 
Protein Synonyms/Alias
 ACOAT 
Gene Name
 argD 
Gene Synonyms/Alias
 Rv1655; MT1693; MTCY06H11.20 
Created Date
 July 27, 2013 
Organism
 Mycobacterium tuberculosis 
NCBI Taxa ID
 1773 
Lysine Modification
Position
Peptide
Type
References
314RRAEVLGKSLRHGIEpupylation[1]
Reference
 [1] Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .
 Festa RA, McAllister F, Pearce MJ, Mintseris J, Burns KE, Gygi SP, Darwin KH.
 PLoS One. 2010 Jan 6;5(1):e8589. [PMID: 20066036] 
Functional Description
  
Sequence Annotation
 REGION 224 227 Pyridoxal phosphate binding (By
 BINDING 139 139 Pyridoxal phosphate; via carbonyl oxygen
 BINDING 142 142 N2-acetyl-L-ornithine (By similarity).
 BINDING 281 281 N2-acetyl-L-ornithine (By similarity).
 BINDING 282 282 Pyridoxal phosphate (By similarity).
 MOD_RES 2 2 N-acetylthreonine; partial.
 MOD_RES 253 253 N6-(pyridoxal phosphate)lysine (By
 CROSSLNK 314 314 Isoglutamyl lysine isopeptide (Lys-Gln)  
Keyword
 Acetylation; Amino-acid biosynthesis; Aminotransferase; Arginine biosynthesis; Complete proteome; Cytoplasm; Isopeptide bond; Pyridoxal phosphate; Reference proteome; Transferase; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 400 AA 
Protein Sequence
MTGASTTTAT MRQRWQAVMM NNYGTPPIAL ASGDGAVVTD VDGRTYIDLL GGIAVNVLGH 60
RHPAVIEAVT RQMSTLGHTS NLYATEPGIA LAEELVALLG ADQRTRVFFC NSGAEANEAA 120
FKLSRLTGRT KLVAAHDAFH GRTMGSLALT GQPAKQTPFA PLPGDVTHVG YGDVDALAAA 180
VDDHTAAVFL EPIMGESGVV VPPAGYLAAA RDITARRGAL LVLDEVQTGM GRTGAFFAHQ 240
HDGITPDVVT LAKGLGGGLP IGACLAVGPA AELLTPGLHG STFGGNPVCA AAALAVLRVL 300
ASDGLVRRAE VLGKSLRHGI EALGHPLIDH VRGRGLLLGI ALTAPHAKDA EATARDAGYL 360
VNAAAPDVIR LAPPLIIAEA QLDGFVAALP AILDRAVGAP 400 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003992; F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity; IEA:HAMAP.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006526; P:arginine biosynthetic process; IEA:HAMAP.
 GO:0040007; P:growth; IMP:MTBBASE. 
Interpro
 IPR005814; Aminotrans_3.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR004636; Trfase_AcOrn/SuccOrn_fam. 
Pfam
 PF00202; Aminotran_3 
SMART
  
PROSITE
 PS00600; AA_TRANSFER_CLASS_3 
PRINTS