CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005194
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Elongation factor Tu 
Protein Synonyms/Alias
 EF-Tu 
Gene Name
 tuf 
Gene Synonyms/Alias
 MPN_665; MP177 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
5***MAREKFDRSKPHacetylation[1]
38AICTVLAKEGKSAATacetylation[1]
52TRYDQIDKAPEEKARacetylation[1]
57IDKAPEEKARGITINacetylation[1]
74HVEYSSDKRHYAHVDacetylation[1]
177IIYGSALKALEGDPKacetylation[1]
184KALEGDPKWEAKIHDacetylation[1]
263VTGIEMFKKELDSAMacetylation[1]
285LLRGVDRKEVERGQVacetylation[1]
306IKPHKKFKAEIYALKacetylation[1]
313KAEIYALKKEEGGRHacetylation[1]
374IACEKGSKFSIREGGacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity). 
Sequence Annotation
 NP_BIND 19 26 GTP (By similarity).
 NP_BIND 81 85 GTP (By similarity).
 NP_BIND 136 139 GTP (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Elongation factor; GTP-binding; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 394 AA 
Protein Sequence
MAREKFDRSK PHVNVGTIGH IDHGKTTLTA AICTVLAKEG KSAATRYDQI DKAPEEKARG 60
ITINSAHVEY SSDKRHYAHV DCPGHADYIK NMITGAAQMD GAILVVSATD SVMPQTREHI 120
LLARQVGVPR MVVFLNKCDI ATDEEVQELV AEEVRDLLTS YGFDGKNTPI IYGSALKALE 180
GDPKWEAKIH DLMNAVDEWI PTPEREVDKP FLLAIEDTMT ITGRGTVVTG RVERGELKVG 240
QEIEIVGLRP IRKAVVTGIE MFKKELDSAM AGDNAGVLLR GVDRKEVERG QVLAKPGSIK 300
PHKKFKAEIY ALKKEEGGRH TGFLNGYRPQ FYFRTTDVTG SISLPENTEM VLPGDNTSIT 360
VELIAPIACE KGSKFSIREG GRTVGAGSVT EVLE 394 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:HAMAP.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0003746; F:translation elongation factor activity; IEA:HAMAP.
 GO:0006184; P:GTP catabolic process; IEA:GOC. 
Interpro
 IPR000795; EF_GTP-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR009001; Transl_elong_EF1A/Init_IF2_C.
 IPR004161; Transl_elong_EFTu/EF1A_2.
 IPR004541; Transl_elong_EFTu/EF1A_bac/org.
 IPR004160; Transl_elong_EFTu/EF1A_C.
 IPR009000; Transl_elong_init/rib_B-barrel. 
Pfam
 PF00009; GTP_EFTU
 PF03144; GTP_EFTU_D2
 PF03143; GTP_EFTU_D3 
SMART
  
PROSITE
 PS00301; EFACTOR_GTP 
PRINTS
 PR00315; ELONGATNFCT.