UniProt Accession

 CY561_HUMAN; P49447; B2RE96; D3DU11; Q5BJG9; Q9BU05; Q9BWR9 

Genbank Protein ID

 U29462; U29460; U29461; U29464; U29469; BT007096; AK316606; CH471109; CH471109; CH471109; BC000021; BC002976; BC091485; U06715 

Genbank Nucleotide ID

 AAC50212.1; AAC50212.1; AAC50212.1; AAC50212.1; AAC50212.1; AAP35760.1; BAG38193.1; EAW94322.1; EAW94323.1; EAW94326.1; AAH00021.1; AAH02976.1; AAH91485.1; AAA50952.1 

Protein Name

 Cytochrome b561 

Protein Synonyms/Alias

 Cytochrome b-561 

Gene Name

 CYB561 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
225	ILTRADWKRPSQAEE	ubiquitination	[1]
240	QALSMDFKTLTEGDS	ubiquitination	[1, 2, 3]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Secretory vesicle-specific electron transport protein. 

Sequence Annotation

 DOMAIN 19 220 Cytochrome b561.
 METAL 53 53 Iron (heme axial ligand) (Potential).
 METAL 87 87 Iron (heme axial ligand) (Potential).
 METAL 91 91 Iron (heme axial ligand) (Potential).
 METAL 109 109 Iron (heme axial ligand) (Potential).
 METAL 121 121 Iron (heme axial ligand) (Potential).
 METAL 160 160 Iron (heme axial ligand) (Potential).
 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 Acetylation; Complete proteome; Electron transport; Heme; Iron; Membrane; Metal-binding; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 251 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0000293; F:ferric-chelate reductase activity; ISS:HGNC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0022865; F:transmembrane electron transfer carrier; NAS:UniProtKB.
 GO:0022900; P:electron transport chain; NAS:UniProtKB. 

Interpro

 IPR006593; Cyt_b561/ferric_Rdtase_TM.
 IPR004877; Cyt_b561_euk. 

Pfam

 PF03188; Cytochrom_B561 

SMART

 SM00665; B561 

PROSITE

 PS50939; CYTOCHROME_B561 

PRINTS