CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022627
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Plectin 
Protein Synonyms/Alias
 PCN; PLTN; Plectin-1; Plectin-6 
Gene Name
 Plec 
Gene Synonyms/Alias
 Plec1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1307EIERHGEKVEECQKFacetylation[1]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123
Functional Description
 Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics. 
Sequence Annotation
 DOMAIN 181 411 Actin-binding.
 DOMAIN 185 293 CH 1.
 DOMAIN 306 408 CH 2.
 REPEAT 653 727 Spectrin 1.
 REPEAT 748 832 Spectrin 2.
 REPEAT 845 938 Spectrin 3.
 REPEAT 1323 1423 Spectrin 4.
 REPEAT 2795 2832 Plectin 1.
 REPEAT 2833 2870 Plectin 2.
 REPEAT 2871 2908 Plectin 3.
 REPEAT 2909 2946 Plectin 4.
 REPEAT 2947 2984 Plectin 5.
 REPEAT 2988 3022 Plectin 6.
 REPEAT 3123 3160 Plectin 7.
 REPEAT 3161 3198 Plectin 8.
 REPEAT 3199 3236 Plectin 9.
 REPEAT 3237 3274 Plectin 10.
 REPEAT 3275 3312 Plectin 11.
 REPEAT 3315 3350 Plectin 12.
 REPEAT 3492 3529 Plectin 13.
 REPEAT 3530 3567 Plectin 14.
 REPEAT 3568 3605 Plectin 15.
 REPEAT 3606 3643 Plectin 16.
 REPEAT 3647 3681 Plectin 17.
 REPEAT 3827 3864 Plectin 18.
 REPEAT 3865 3902 Plectin 19.
 REPEAT 3903 3940 Plectin 20.
 REPEAT 3941 3978 Plectin 21.
 REPEAT 3982 4015 Plectin 22.
 REPEAT 4070 4107 Plectin 23.
 REPEAT 4108 4145 Plectin 24.
 REPEAT 4146 4183 Plectin 25.
 REPEAT 4184 4221 Plectin 26.
 REPEAT 4225 4259 Plectin 27.
 REPEAT 4272 4312 Plectin 28.
 REPEAT 4415 4452 Plectin 29.
 REPEAT 4453 4490 Plectin 30.
 REPEAT 4491 4528 Plectin 31.
 REPEAT 4529 4566 Plectin 32.
 REPEAT 4567 4604 Plectin 33.
 REGION 1 1478 Globular 1 (By similarity).
 REGION 1479 2762 Central fibrous rod domain (By
 REGION 2763 4691 Globular 2 (By similarity).
 REGION 4257 4307 Binding to intermediate filaments (By
 REGION 4632 4647 4 X 4 AA tandem repeats of G-S-R-X.
 MOD_RES 212 212 Phosphoserine.
 MOD_RES 728 728 Phosphoserine.
 MOD_RES 823 823 Phosphothreonine.
 MOD_RES 1443 1443 Phosphoserine.
 MOD_RES 1729 1729 Phosphoserine.
 MOD_RES 2788 2788 Phosphotyrosine.
 MOD_RES 3040 3040 Phosphotyrosine.
 MOD_RES 3098 3098 N6-acetyllysine (By similarity).
 MOD_RES 3369 3369 Phosphotyrosine.
 MOD_RES 3427 3427 N6-acetyllysine (By similarity).
 MOD_RES 3797 3797 Phosphotyrosine.
 MOD_RES 4037 4037 Phosphothreonine (By similarity).
 MOD_RES 4389 4389 Phosphoserine.
 MOD_RES 4391 4391 Phosphoserine.
 MOD_RES 4392 4392 Phosphoserine (By similarity).
 MOD_RES 4393 4393 Phosphoserine.
 MOD_RES 4396 4396 Phosphoserine.
 MOD_RES 4397 4397 Phosphoserine.
 MOD_RES 4398 4398 Phosphoserine (By similarity).
 MOD_RES 4399 4399 Phosphoserine.
 MOD_RES 4403 4403 Phosphoserine (By similarity).
 MOD_RES 4418 4418 Phosphothreonine (By similarity).
 MOD_RES 4546 4546 Phosphothreonine; by CDK1 (By
 MOD_RES 4620 4620 Phosphoserine (By similarity).
 MOD_RES 4622 4622 Phosphotyrosine.
 MOD_RES 4625 4625 Phosphoserine (By similarity).
 MOD_RES 4629 4629 Phosphoserine.
 MOD_RES 4633 4633 Phosphoserine.
 MOD_RES 4649 4649 Phosphoserine (By similarity).  
Keyword
 3D-structure; Acetylation; Actin-binding; Alternative splicing; Cell junction; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4691 AA 
Protein Sequence
MSGEDSEVRP VAVAEGSSNG SSGSPSPGDT LPWNLGKTQR SRRSGGGSVG NGSVLDPAER 60
AVIRIADERD RVQKKTFTKW VNKHLIKHWR AEAQRHISDL YEDLRDGHNL ISLLEVLSGD 120
SLPRERDVIR SVRLPREKGR MRFHKLQNVQ IALDYLRHRQ VKLVNIRNDD IADGNPKLTL 180
GLIWTIILHF QISDIQVSGQ SEDMTAKEKL LLWSQRMVEG YQGLRCDNFT TSWRDGRLFN 240
AIIHRHKPML IDMNKVYRQT NLENLDQAFS VAERDLGVTR LLDPEDVDVP QPDEKSIITY 300
VSSLYDAMPR VPGAQDGVRA NELQLRWQEY RELVLLLLQW IRHHTAAFEE RKFPSSFEEI 360
EILWCQFLKF KETELPAKEA DKNRSKVIYQ SLEGAVQAGQ LKIPPGYHPL DVEKEWGKLH 420
VAILEREKQL RSEFERLECL QRIVSKLQME AGLCEEQLNQ ADALLQSDIR LLASGKVAQR 480
AGEVERDLDK ADGMIRLLFN DVQTLKDGRH PQGEQMYRRV YRLHERLVAI RTEYNLRLKA 540
GVGAPVTQVT LQSTQRRPEL EDSTLRYLQD LLAWVEENQR RIDSAEWGVD LPSVEAQLGS 600
HRGMHQSIEE FRAKIERARN DESQLSPATR GAYRDCLGRL DLQYAKLLNS SKARLRSLES 660
LHGFVAAATK ELMWLNEKEE EEVGFDWSDR NTNMAAKKES YSALMRELEM KEKKIKEIQN 720
TGDRLLREDH PARPTVESFQ AALQTQWSWM LQLCCCIEAH LKENTAYFQF FSDVREAEEQ 780
LQKLQETLRR KYSCDRTITV TRLEDLLQDA QDEKEQLNEY KGHLSGLAKR AKAIVQLKPR 840
NPAHPVRGHV PLIAVCDYKQ VEVTVHKGDQ CQLVGPAQPS HWKVLSGSSS EAAVPSVCFL 900
VPPPNQEAQE AVARLEAQHQ ALVTLWHQLH VDMKSLLAWQ SLSRDIQLIR SWSLVTFRTL 960
KPEEQRQALR NLELHYQAFL RDSQDAGGFG PEDRLVAERE YGSCSRHYQQ LLQSLEQGEQ 1020
EESRCQRCIS ELKDIRLQLE ACETRTVHRL RLPLDKDPAR ECAQRIAEQQ KAQAEVEGLG 1080
KGVARLSAEA EKVLALPEPS PAAPTLRSEL ELTLGKLEQV RSLSAIYLEK LKTISLVIRS 1140
TQGAEEVLKT HEEQLKEAQA VPATLQELEA TKASLKKLRA QAEAQQPVFN TLRDELRGAQ 1200
EVGERLQQRH GERDVEVERW RERVTQLLER WQAVLAQTDV RQRELEQLGR QLRYYRESAD 1260
PLSAWLQDAK RRQEQIQAVP IANCQAAREQ LRQEKALLEE IERHGEKVEE CQKFAKQYIN 1320
AIKDYELQLI TYKAQLEPVA SPAKKPKVQS GSESVIQEYV DLRTRYSELT TLTSQYIKFI 1380
SETLRRMEEE ERLAEQQRAE ERERLAEVEA ALEKQRQLAE AHAQAKAQAE LEAQELQRRM 1440
QEEVARREEA AVDAQQQKRS IQEELQHLRQ SSEAEIQAKA QQVEAAERSR MRIEEEIRVV 1500
RLQLETTERQ RGGAEGELQA LRARAEEAEA QKRQAQEEAE RLRRQVQDES QRKRQAEAEL 1560
ALRVKAEAEA AREKQRALQA LDELRLQAEE AERRLRQAEA ERARQVQVAL ETAQRSAEVE 1620
LQSKRASFAE KTAQLERTLQ EEHVTVAQLR EEAERRAQQQ AEAERAREEA ERELERWQLK 1680
ANEALRLRLQ AEEVAQQKSL AQADAEKQKE EAEREARRRG KAEEQAVRQR ELAEQELEKQ 1740
RQLAEGTAQQ RLAAEQELIR LRAETEQGEQ QRQLLEEELA RLQHEATAAT QKRQELEAEL 1800
AKVRAEMEVL LASKARAEEE SRSTSEKSKQ RLEAEAGRFR ELAEEAARLR ALAEEAKRQR 1860
QLAEEDAARQ RAEAERVLTE KLAAISEATR LKTEAEIALK EKEAENERLR RLAEDEAFQR 1920
RRLEEQAALH KADIEERLAQ LRKASESELE RQKGLVEDTL RQRRQVEEEI MALKVSFEKA 1980
AAGKAELELE LGRIRSNAED TMRSKEQAEL EAARQRQLAA EEEQRRREAE ERVQRSLAAE 2040
EEAARQRKVA LEEVERLKAK VEEARRLRER AEQESARQLQ LAQEAAQKRL QAEEKAHAFV 2100
VQQREEELQQ TLQQEQNMLD RLRSEAEAAR RAAEEAEEAR EQAEREAAQS RKQVEEAERL 2160
KQSAEEQAQA QAQAQAAAEK LRKEAEQEAA RRAQAEQAAL KQKQAADAEM EKHKKFAEQT 2220
LRQKAQVEQE LTTLRLQLEE TDHQKSILDE ELQRLKAEVT EAARQRSQVE EELFSVRVQM 2280
EELGKLKARI EAENRALILR DKDNTQRFLE EEAEKMKQVA EEAARLSVAA QEAARLRQLA 2340
EEDLAQQRAL AEKMLKEKMQ AVQEATRLKA EAELLQQQKE LAQEQARRLQ EDKEQMAQQL 2400
VEETQGFQRT LEAERQRQLE MSAEAERLKL RMVEMSRAQA RAEEDAQRFR KQAEEIGEKL 2460
HRTELATQEK VTLVQTLEIQ RQQSDHDAER LREAIAELER EKEKLKQEAK LLQLKSEEMQ 2520
TVQQEQILQE TQALQKSFLS EKDSLLQRER FIEQEKAKLE QLFQDEVAKA KQLREEQQRQ 2580
QQQMEQEKQE LMASMEEARR RQREAEEGVR RKQEELQHLE QQRQQQEKLL AEENQRLRER 2640
LQRLEEEHRA ALAHSEIATT QAASTKALPN GRDAPDGPSV EAEPEYTFEG LRQKVPAQQL 2700
QEAGILSQEE LQRLAQGHTT VAELTQREDV YRYLKGRSSI AGLLLKPTNE KLSVYTALQR 2760
QLLSPGTALI LLEAQAASGF LLDPVRNRRL TVNEAVKEGV VGPELHHKLL SAERAVTGYK 2820
DPYTGEQISL FQAMKKDLIV RDHGVRLLEA QIATGGIIDP VHSHRVPVDV AYKRGYFDEE 2880
MNRILSDPSD DTKGFFDPNT HENLTYLQLL ERCVEDPETG LRLLPLTDKA AKGGELVYTD 2940
TEARDVFEKA TVSAPFGKFQ GRTVTIWEII NSEYFTAEQR RDLLQQFRTG HITVEKIIKI 3000
VITVVEEHER KGQLCFEGLR ALVPAAELLD SGVISHELYQ QLQRGERSVR EVAEADSVRQ 3060
ALRGTNVIAG VWLEEAGQKL SIYEALKKDL LQPEVAVALL EAQAGTGHII DPATSARLTV 3120
DEAVRAGLVG PELHEKLLSA EKAVTGYRDP YSGQSVSLFQ ALKKGLIPRE QGLRLLDAQL 3180
STGGIVDPSK SHRVPLDVAY ARGYLDKETN RALTSPRDDA RVYHDPSTQE PVTYSQLQQR 3240
CRSDQLTGLS LLPLSEKAVR ARQEEVYSEL QARETLEQAK VEVPVGSFKG RAMTVWELIS 3300
SEYFTEEQRQ ELLRQFRTGK VTVEKVIKIV ITIVEEVETR RQERLSFSGL RAPVPASELL 3360
DAKILSRAQF DQLKDGKTSV KELSEVGSVR TLLQGSGCLA GIYLEDSKEK VTIYEAMRRG 3420
LLRPSTATLL LEAQAATGFL VDPVRNQRLY VHEAVKAGVV GPELHEKLLS AEKAVTGYKD 3480
PYSGNTISLF QAMKKGLVLR DHAIRLLEAQ VATGGIIDPV HSHRLPVDVA YQRGYFDEEM 3540
NRVLADPSDD TKGFFDPNTH ENLTYLQLLE RCVEDPETGL RLLPLKGAEK TEVVETTQVY 3600
TEEETRRAFE ETQIDIPGGG SHGGSSMSLW EVMQSNMIPE DQRARLMADF QAGRVTKERM 3660
IIIIIEIIEK TEIIRQQNLA SYDYVRRRLT AEDLYEARII SLETYNLFRE GTKNLREVLE 3720
MESAWRYLYG TGAVAGVYLP GSRQTLTIYQ ALKKGLLSAE VARLLLEAQA ATGFLLDPVK 3780
GERLTVDEAV RKGLVGPELH DRLLSAERAV TGYRDPYTEQ TISLFQAMKK ELIPAEEALR 3840
LLDAQLATGG IVDPRLGFHL PLEVAYQRGY LNKDTHDQLS EPSEVRSYVD PSTDERLSYT 3900
QLLKRCRRDD PSGQMLLLLS DARKLTFRGL RKQITVEELV RSQVMDEATA LQLQEGLTSI 3960
EEVTKNLQKF LEGTSCIAGV FVDATKERLS VYQAMKKGII RPGTAFELLE AQAATGYVID 4020
PIKGLKLTVE EAVRMGIVGP EFKDKLLSAE RAVTGYKDPY SGKLISLFQA MKKGLILKDH 4080
GIRLLEAQIA TGGIIDPEES HRLPVEVAYK RGLFDEEMNE ILTDPSDDTK GFFDPNTEEN 4140
LTYLQLMERC ITDPQTGLCL LPLKEKKRER KTSSKSSVRK RRVVIVDPET GKEMSVYEAY 4200
RKGLIDHQTY LELSEQECEW EEITISSSDG VVKSMIIDRR SGRQYDIDDA ITKNLIDRSA 4260
LDQYRAGTLS ITEFADMLSG NAGGFRSRSS SVGSSSSYPI SSAGPRTQLA SWSDPTEETG 4320
PVAGILDTET LEKVSITEAM HRNLVDNITG QRLLEAQACT GGIIDPSTGE RFPVTEAVNK 4380
GLVDKIMVDR INLAQKAFCG FEDPRTKTKM SAAQALKKGW LYYEAGQRFL EVQYLTGGLI 4440
EPDTPGRVSL DEALQRGTVD ARTAQKLRDV SAYSKYLTCP KTKLKISYKD ALDRSMVEEG 4500
TGLRLLEAAA QSSKGYYSPY SVSGSGSTAG SRTGSRTGSR AGSRRGSFDA TGSGFSMTFS 4560
SSSYSSSGYG RRYASGPSAS LGGPESAVA 4589 
Gene Ontology
 GO:0043292; C:contractile fiber; IDA:MGI.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0030056; C:hemidesmosome; ISS:UniProtKB.
 GO:0042383; C:sarcolemma; ISS:UniProtKB.
 GO:0031581; P:hemidesmosome assembly; ISS:UniProtKB. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR001101; Plectin_repeat.
 IPR005326; S10_plectin_N.
 IPR018159; Spectrin/alpha-actinin. 
Pfam
 PF00307; CH
 PF00681; Plectin
 PF03501; S10_plectin 
SMART
 SM00033; CH
 SM00250; PLEC
 SM00150; SPEC 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH 
PRINTS