CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014812
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Constitutive coactivator of PPAR-gamma-like protein 1 
Protein Synonyms/Alias
 Oxidative stress-associated Src activator; Protein FAM120A 
Gene Name
 FAM120A 
Gene Synonyms/Alias
 Kiaa0183; Ossa 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
12GFQDYIEKHCPSAVVubiquitination[1]
25VVPVELQKLARGSLVubiquitination[1]
304SDLDAIAKDVFQHSQubiquitination[1]
482GNKIGWEKTGSHAEPubiquitination[1]
677LKRLWLGKAVEDKNRubiquitination[1]
756PDQLQELKIDNLDPRubiquitination[1]
808DGKLFQSKLLKASREubiquitination[1]
816LLKASREKTPLIDLCubiquitination[1]
832GQAEQAAKVEKMRQSubiquitination[1]
930SDSSRTSKSQGGVQPacetylation[2]
930SDSSRTSKSQGGVQPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II (By similarity). May participate in mRNA transport in the cytoplasm. 
Sequence Annotation
 REGION 339 403 Interaction with YES1, SRC and FYN (By
 REGION 827 1112 RNA binding (By similarity).
 MOD_RES 980 980 Omega-N-methylated arginine (By
 MOD_RES 1021 1021 Phosphoserine (By similarity).
 MOD_RES 1042 1042 Phosphoserine (By similarity).  
Keyword
 Cell membrane; Complete proteome; Cytoplasm; Membrane; Methylation; Phosphoprotein; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1112 AA 
Protein Sequence
MGVQGFQDYI EKHCPSAVVP VELQKLARGS LVGGGRQRPP QTPLRLLVDA DNCLHRLYGG 60
FYTDWVSGGQ WNHMLGYLAA LAKACFGGNI ELFVFFNGAL EKARLHEWVK RQGNERQTAQ 120
QIVSHVQNKG TPPPKVWFLP PVCMAHCIRL ALIRFHVKVA QSIEDHHQEV IGFCRENGFH 180
GLVAYDSDYA LCNIPYYFSA HALKLSRNGK SLTTSQYLMH EVAKQLDLNP NRFPIFAALL 240
GNHILPDEDL ASFHWSLLGP EHPLASLKVR AHQLVLPPCD VVIKAVADYV RNIHDTSDLD 300
AIAKDVFQHS QSRTDDKVIR FKRAVGYYSA TSKPMPFHPP HYLARPNPFG MPGMVPPYVP 360
PQMLNIPQTS LQAKPAVPQV PSPGGTPGQA PYPYSLSEPA LTLDTSGKNL TEQNSYSNIP 420
HEGKHTPLYE RSSPINLAQS GSPNHVDSAY FPGSSTSSSS DNDEGGGGAT NHISGNKIGW 480
EKTGSHAEPL ARGDPGDQVK VEGSSTASSG SQLAEGKGSH MGTVQPIPCL LSMPTRNHMD 540
ITTPPLPPVA PEVLRVAEHR HKKGLMYPYI FHILTKGEIK IAVSIEDEAN KDLPPAALLY 600
RPVRQYVYGV LFSLAESRKK TERLAFRKNR LPPEFSPLII KEWAAYKGKS PQTPELVEAL 660
AFREWTCPNL KRLWLGKAVE DKNRRMRAFL ACMRSDTPAM LNPANVPTHL MVLCCVLRYM 720
VQWPGARILR RQELDAFLAQ ALSPKLYEPD QLQELKIDNL DPRGIQLSAL FMSGVDMALF 780
ANDACGQPIP WEHCCPWMYF DGKLFQSKLL KASREKTPLI DLCDGQAEQA AKVEKMRQSI 840
LEGLSFSRQN HPLPFPPPPA LPFYPASVYP RHFGPVPPSQ GRGRGFAGVC GFGGHYGETV 900
ATGPYRAFRV TAASGHCGAF SGSDSSRTSK SQGGVQPIPS QGGKLEIAGT VVGHWAGSRR 960
GRGGRGPFPL QVVSVGGPAR GRPRGVISTP VIRTFGRGGR YYGRGYKSQG AIQGRPPYAA 1020
SAEEVAKELK SKSGESKSSA VSLAENGVMA EEKPVPQLNG STGDPRVPSH SESALNNDSK 1080
PCNTNPHLNA LSTDSACRRE AALEAAVLNK EE 1112 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW. 
Interpro
 IPR026783; Coact_PPARg-like_1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS