UniProt Accession

 Q5T9V0_HUMAN; Q5T9V0 

Genbank Protein ID

 AL139410 

Genbank Nucleotide ID

  

Protein Name

 RUN and SH3 domain-containing protein 1 

Protein Synonyms/Alias

  

Gene Name

 RUSC1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
74	TGQLQEQKKGLLIAV	ubiquitination	[1]
101	AARNLVQKAQLGDSR	ubiquitination	[1, 2]
301	QSLRGTSKEAASDPS	ubiquitination	[2, 3]
393	ENENGALKSRRPSSW	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 492 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA. 

Interpro

 IPR004012; Run.
 IPR001452; SH3_domain. 

Pfam

 PF02759; RUN
 PF00018; SH3_1 

SMART

 SM00593; RUN
 SM00326; SH3 

PROSITE

 PS50826; RUN
 PS50002; SH3 

PRINTS