UniProt Accession

 CATW_HUMAN; P56202; Q86VT4 

Genbank Protein ID

 AF013611; AF015954; AF055903; AP001201; BC048255 

Genbank Nucleotide ID

 AAB82449.1; AAB82457.1; AAC32181.1; AAH48255.1 

Protein Name

 Cathepsin W 

Protein Synonyms/Alias

 Lymphopain 

Gene Name

 CTSW 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
39	GPQPLELKEAFKLFQ	ubiquitination	[1]
220	KDYPFQGKVRAHRCH	ubiquitination	[2]
340	WGAQWGEKGYFRLHR	ubiquitination	[1]
356	SNTCGITKFPLTARV	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
 Xu G, Paige JS, Jaffrey SR.
 Nat Biotechnol. 2010 Aug;28(8):868-73. [PMID: 20639865] 

Functional Description

 May have a specific function in the mechanism or regulation of T-cell cytolytic activity. 

Sequence Annotation

 ACT_SITE 153 153 By similarity.
 ACT_SITE 291 291 By similarity.
 ACT_SITE 331 331 By similarity.
 CARBOHYD 50 50 N-linked (GlcNAc...) (Potential).
 CARBOHYD 205 205 N-linked (GlcNAc...) (Potential).
 DISULFID 150 191 By similarity.
 DISULFID 184 226 By similarity.
 DISULFID 284 352 By similarity.  

Keyword

 Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase; Polymorphism; Protease; Reference proteome; Signal; Thiol protease; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 376 AA 

Protein Sequence

Gene Ontology

 GO:0008234; F:cysteine-type peptidase activity; TAS:ProtInc.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR025661; Pept_asp_AS.
 IPR025660; Pept_his_AS.
 IPR013128; Peptidase_C1A.
 IPR000668; Peptidase_C1A_C.
 IPR013201; Prot_inhib_I29. 

Pfam

 PF08246; Inhibitor_I29
 PF00112; Peptidase_C1 

SMART

 SM00848; Inhibitor_I29
 SM00645; Pept_C1 

PROSITE

 PS00640; THIOL_PROTEASE_ASN
 PS00139; THIOL_PROTEASE_CYS
 PS00639; THIOL_PROTEASE_HIS 

PRINTS

 PR00705; PAPAIN.