| Tag | Content |
|---|
| CPLM ID | CPLM-016069 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pleckstrin homology domain-containing family A member 8 |
Protein Synonyms/Alias | PH domain-containing family A member 8; Phosphatidylinositol-four-phosphate adapter protein 2; FAPP-2; Phosphoinositol 4-phosphate adapter protein 2 |
Gene Name | Plekha8 |
Gene Synonyms/Alias | Fapp2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 416 | KRGLKFLKGFLTEVK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4- phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity). |
Sequence Annotation | DOMAIN 1 93 PH.
REGION 330 473 Glycolipid transfer protein homology
MOD_RES 139 139 Phosphothreonine (By similarity).
MOD_RES 145 145 Phosphoserine (By similarity).
MOD_RES 153 153 Phosphothreonine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Golgi apparatus; Lipid transport; Lipid-binding; Membrane; Phosphoprotein; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 519 AA |
Protein Sequence | MEGVLYKWTN YLSGWQPRWF LLCGGILSYY DSPEDAWKGC KGSIQMAVCE IQVHSVDNTR 60
MDLIIPGEQY FYLKARSVAE RQRWLVALGS AKACLTDSRT QKEKEFAENT ENLKTKMSEL 120
RLYCDLLVQQ VDKTKEVATA GVTDSEEGID VGTLLKSTCN TFLKTLEECM QIANAAFTSE 180
LLYHTPPGSP QLAVLKSSKM KHPIIPIHNS LERSMELNSC ENGSLSIEVN GDEEILMKTK 240
SSLYLKSTEV DCSISSEENT DDNVTVQGEI MKEDGEENLE SHDKDPAQPG SDSVCSPESP 300
WEDNEEVIPT FFSTMNTSFS DIELLEDSGI PTEAFLASCY AVVPVLDKLG PTVFAPVKMD 360
LVGNIKKVNQ KYITNKEEFT TLQKIVLHEV EADVAQVRNS ATEALLWLKR GLKFLKGFLT 420
EVKNGEKDIQ TALNNAYGKT LRQHHGWVVR GVFALALRAA PSYEDFVAAL TIKEGDHQKE 480
AFSAGMQRDL SLYLPAMEKQ LAILDTLYEI HGLESDEVV 519 |
Gene Ontology | GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0005802; C:trans-Golgi network; ISS:UniProtKB. GO:0097001; F:ceramide binding; ISS:UniProtKB. GO:0051861; F:glycolipid binding; ISS:UniProtKB. GO:0017089; F:glycolipid transporter activity; ISS:UniProtKB. GO:0070273; F:phosphatidylinositol-4-phosphate binding; ISS:UniProtKB. GO:0035621; P:ER to Golgi ceramide transport; ISS:UniProtKB. GO:0046836; P:glycolipid transport; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |