UniProt Accession

 FKBP3_MOUSE; Q62446; Q9WTJ7 

Genbank Protein ID

 AF135595; AF110812; BC002122; U62545 

Genbank Nucleotide ID

 AAD25097.1; AAD20598.1; AAH02122.1; AAB05769.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase FKBP3 

Protein Synonyms/Alias

 PPIase FKBP3; 25 kDa FK506-binding protein; 25 kDa FKBP; FKBP-25; FK506-binding protein 3; FKBP-3; Immunophilin FKBP25; Rapamycin-selective 25 kDa immunophilin; Rotamase 

Gene Name

 Fkbp3 

Gene Synonyms/Alias

 Fkbp25 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
27	LPKKDIIKFLQDHGS	ubiquitination	[1]
42	DSFLAEHKLLGNIKN	ubiquitination	[1]
48	HKLLGNIKNVAKTAN	ubiquitination	[1]
70	YNHLFESKRFKGTET	ubiquitination	[1]
80	KGTETISKVSEQVKN	acetylation	[2]
80	KGTETISKVSEQVKN	ubiquitination	[1]
94	NVKLSDDKPKDSKSE	acetylation	[3]
96	KLSDDKPKDSKSEET	acetylation	[3]
99	DDKPKDSKSEETLDE	acetylation	[2]
121	SILKKGDKTNFPKKG	acetylation	[3]
160	SKKKKNAKPLSFKVG	ubiquitination	[1]
170	SFKVGVGKVIRGWDE	acetylation	[4]
170	SFKVGVGKVIRGWDE	ubiquitination	[1]
200	EPEWAYGKKGQPDAK	acetylation	[2]
200	EPEWAYGKKGQPDAK	succinylation	[2]
200	EPEWAYGKKGQPDAK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins (By similarity). 

Sequence Annotation

 DOMAIN 128 224 PPIase FKBP-type.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 36 36 Phosphoserine (By similarity).
 MOD_RES 152 152 Phosphoserine (By similarity).
 MOD_RES 170 170 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Isomerase; Nucleus; Phosphoprotein; Reference proteome; Rotamase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 224 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IBA:RefGenome.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005528; F:FK506 binding; IBA:RefGenome.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW. 

Interpro

 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom. 

Pfam

 PF00254; FKBP_C 

SMART

  

PROSITE

 PS50059; FKBP_PPIASE 

PRINTS