| Tag | Content |
|---|
| CPLM ID | CPLM-011192 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Adenylate cyclase type 5 |
Protein Synonyms/Alias | ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5 |
Gene Name | Adcy5 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 705 | GFEDPKDKNAQESAN | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | This is a membrane-bound, calcium-inhibitable adenylyl cyclase. |
Sequence Annotation | DOMAIN 470 597 Guanylate cyclase 1.
DOMAIN 1072 1211 Guanylate cyclase 2.
METAL 475 475 Magnesium 1 (By similarity).
METAL 475 475 Magnesium 2 (By similarity).
METAL 476 476 Magnesium 2; via carbonyl oxygen (By
METAL 519 519 Magnesium 1 (By similarity).
METAL 519 519 Magnesium 2 (By similarity).
MOD_RES 8 8 Phosphoserine (By similarity).
CARBOHYD 871 871 N-linked (GlcNAc...) (Potential).
CARBOHYD 888 888 N-linked (GlcNAc...) (Potential).
CARBOHYD 973 973 N-linked (GlcNAc...) (Potential). |
Keyword | ATP-binding; cAMP biosynthesis; Cell projection; Cilium; Complete proteome; Glycoprotein; Lyase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1262 AA |
Protein Sequence | MSGSKSVSPP GYAAQTAASP APRGGPEHRA AWGEADSRAN GYPHAPGGST RGSTKRSGGA 60
VTPQQQQRLA SRWRGGDDDE DPPLSGDDPL VGGFGFSFRS KSAWQERGGD DGGRGSRRQR 120
RGAAGGGSTR APPAGGSGSS AAAAAAAGGT EVRPRSVEVG LEERRGKGRA AEELEPGTGT 180
VEDGDGSEDG GSSVASGSGT GTVLSLGACC LALLQIFRSK KFPSDKLERL YQRYFFRLNQ 240
SSLTMLMAVL VLVCLVMLAF HAARPPLQVV YLAVLAAAVG VILIMAVLCN RAAFHQDHMG 300
LACYALIAVV LAVQVVGLLL PQPRSASEGI WWTVFFIYTI YTLLPVRMRA AVLSGVLLSA 360
LHLAISLHTN AQDQFLLKQL VSNVLIFSCT NIVGVCTHYP AEVSQRQAFQ ETRECIQARL 420
HSQRENQQQE RLLLSVLPRH VAMEMKADIN AKQEDMMFHK IYIQKHDNVS ILFADIEGFT 480
SLASQCTAQE LVMTLNELFA RFDKLAAENH CLRIKILGDC YYCVSGLPEA RADHAHCCVE 540
MGMDMIEAIS SVREVTGVNV NMRVGIHSGR VHCGVLGLRK WQFDVWSNDV TLANHMEAGG 600
KAGRIHITKA TLNYLNGDYE VEPGCGGERN AYLKEHSIET FLILRCTQKR KEEKAMIAKM 660
NRQRTNSIGH NPPHWGAERP FYNHLGGNQV SKEMKRMGFE DPKDKNAQES ANPEDEVDEF 720
LGRAIDARSI DRLRSEHVRK FLLTFREPDL EKKYSKQVDD RFGAYVACAS LVFLFICFVQ 780
ITIVPHSLFM LSFYLSCFLL LALVVFISVI YACVKLFPTP LQTLSRKIVR SKKNSTLVGV 840
FTITLVFLSA FVNMFMCNSK NLVGCLAEEH NITVNQVNAC HVMESAFNYS LGDEQGFCGS 900
PQSNCNFPEY FTYSVLLSLL ACSVFLQISC IGKLVLMLAI ELIYVLIVEV PGVTLFDNAD 960
LLVTANAIDF SNNGTSQCPE HATKVALKVV TPIIISVFVL ALYLHAQQVE STARLDFLWK 1020
LQATEEKEEM EELQAYNRRL LHNILPKDVA AHFLARERRN DELYYQSCEC VAVMFASIAN 1080
FSEFYVELEA NNEGVECLRL LNEIIADFDE IISEDRFRQL EKIKTIGSTY MAASGLNDST 1140
YDKAGKTHIK ALADFAMKLM DQMKYINEHS FNNFQMKIGL NIGPVVAGVI GARKPQYDIW 1200
GNTVNVASRM DSTGVPDRIQ VTTDMYQVLA ANTYQLECRG VVKVKGKGEM MTYFLNGGPP 1260
LS 1262 |
Gene Ontology | GO:0005768; C:endosome; IDA:RGD. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0045121; C:membrane raft; IDA:RGD. GO:0005886; C:plasma membrane; IDA:RGD. GO:0072372; C:primary cilium; ISS:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0008294; F:calcium- and calmodulin-responsive adenylate cyclase activity; IDA:RGD. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0035556; P:intracellular signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |