CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032723
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acetyl-CoA carboxylase, putative 
Protein Synonyms/Alias
  
Gene Name
 TGVEG_051970 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Toxoplasma gondii 
NCBI Taxa ID
 5811 
Lysine Modification
Position
Peptide
Type
References
2422PPGICEIKYRAADQKacetylation[1, 2]
Reference
 [1] Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.
 Jeffers V, Sullivan WJ Jr.
 Eukaryot Cell. 2012 Jun;11(6):735-42. [PMID: 22544907]
 [2] Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii.
 Xue B, Jeffers V, Sullivan WJ, Uversky VN.
 Mol Biosyst. 2013 Apr 5;9(4):645-57. [PMID: 23403842
Functional Description
  
Sequence Annotation
  
Keyword
 Biotin; Complete proteome; Ligase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2612 AA 
Protein Sequence
MPTRTHARVR SVCTMGVVSR AAAASWPLAS RARDSGALWG GLENDGEAGN RFPVTFSLSG 60
ETNGKPQTHH CSRPIDHRET RRGNGGVSGF FVFLFLLFFS PLSATAGPTQ SGNLLPYTGG 120
PWESSRRPED GHRAFSLASS QPIFFGPPAA SSGPSHVGNP HGSDLVPPSS LSPSSSVVSS 180
FAVSSPVSAH GLRKRRPMLP FSRSRRSMTF LSGPPISASP SSVSSSARFP SRSCSSLSLH 240
REARDSPRCH GVSCSVFESP ELRHATFLSH PVPHSPLSSP ATPASFSSRS APGNQSAIQA 300
STTESRVGER EGEATPTRVG DGEGDPLADY VRKHGGKRVI RRVLIANNGM AATKSIFSMR 360
QWAYMELGDD KLLEFVVMAT PEDMRANPEF IRRADKIVEV PGGPNRNNYA NVDLICQIAV 420
QEKVDAVWPG WGHASENPNL PRRLSELGIT FIGPSATVMA ALGDKIAANI LAQTAGVPSI 480
PWSGDSLKAT LDSTGAIPRD IFDQATVKSV EECEKVADRI GYPMMIKASE GGGGKGIRMV 540
DRKEQVRGAY EQVVAEVPGS PVFMMQLCTA ARHIEVQIVG DEDGQAVALS GRDCSTQRRF 600
QKIFEEAPPT TVVPPHTMKE MEKAAQRLTQ SLGYVGAGTV EYLYNRKDDK FFFLELNPRL 660
QVEHPVSEGV TGVNLPAAQL QVAMGIPLWR IPDIRRFFGR DPNAGDRIDF INEDYLPIQR 720
HVLASRVTAE NPDEGFKPTS GRVDRLEFQP LENVWGYFSV GASGGVHEYA DSQFGHIFAT 780
GKNREEARKK LVLGLKRVDV RGEIRTPIEY LVQLLEDKDF IENRIDTSWL DKLIKQRKRL 840
GEKKVEKAHV VLAAVLFRAI RALKEKEQRV LSALQRGQRY IHDLASLNTV SQEVVYEDQR 900
FSFEVSRTGP QLYVLKLNTQ EVECVVREQP DGSYIVLFPG EKSHKFNGRE EPLGLRLQVD 960
GTTVLLPNVF DPSELRSDVT GKVVRYLVPD KGQVKKGEPY VEVEAMKMIM TLTAGETGVL 1020
SHTKSPGSVV NTGDVLGTLA LEDPSRVKKI VDFSGLLDLP RVKKREAADA REKQTEGAGA 1080
TFSLFGSPED EAAMRLRLAM EGYEQDVEST VQKLAFPSVD SRNLQTKKEK LTELLVELFQ 1140
SFLSVDEHFA SVQGGEVAVD GPAAEKKVQD PATLLKLKLA HSRLQPRIQL VLSLLRALQN 1200
FPNFFPEWTM PVSLELCLTR LAALHGRAYG QIALEAIRLL RSFRVAPFEQ RVQRLKAELL 1260
QLPSTSKAGS ASERETNVRR AERIARSGTA SAGIDLLSHL FGDGSVSLKA LEVAVRRHYR 1320
GFPIDALHTE LFEVETQDGS KKEIPVAFWS FRQGDLTGAE APLRTGVMGA FQSLEEVQEV 1380
GDRLLGRLRQ FDEEKRKDEG LGESHRERED TQEPRNVCLF ALTTPMDFGT EEEKLKSRMQ 1440
GIIHSLQPSL RSADVRLAAV HVPQVNKSCR MFNFLASDGF DESRIRRDLC PTVPSLIELN 1500
RLQTSFDLTR LDALDPNTQA YLALPRLEPS AKGEVSPSSP STGPGAASAQ GASSTSKKPV 1560
SQAQAPQNVF VRRLIFENEV KSDFSDLPRI LLDLLDVLDR CASDPRVSAT ASGRLFLHIV 1620
SPLNLASAKA VTEHFHKMMK RFRSEHNERL LRLRVDQIEV KMHLRKGGSG SDGEKRSSRE 1680
EGAEATGSQA KEKERLQVLR LSVSSHQGSW LHTKASEDVP HVLTGDPIAQ RSFVFDEGEE 1740
TDAEGFVAQA SPAGSGAEGA DGAKSRATEK TGQREGDAAP VVSREPPEAE GLLGRISVGL 1800
KTLRGTQTSA TGSAGAGEMP AASSSPPGRW EGGDRKKQGL LSVSRREENE FFRHEKDADP 1860
YPEVDRIAMA RSAARRAGST YIFDFLGLME IALLQSWQTH LKEKGEKDGG VGGWDEAVPR 1920
DLFKAEAFKV SAQGTLYLDP DWRVADNKIG MVGFLITLKT PEYPSGRQVV LLGNDITFQG 1980
GSFGVPEHLF FTQVSRFSRE QGLPRVYIAC NSGARIGLYE NLKDKIKVEW NDASNPSLGF 2040
KNLYLSAEDY AALPPGVVSG HFEEAMNGDQ RRFVLDAIIG DPDKFIGVEN LRGSGTIAGE 2100
TSRAYDETFT LSYVTGRSVG IGAYIVRLAQ RTIQMVRGPL LLTGYQALNK LLGREVYASQ 2160
DQLGGPEVMF RNGVSHLVVQ NDQEGMKEVL RWLAYTPKTA RDSVSSAEMF SSDPVEREVA 2220
FTPTKAPYDV RHMLAGYTKE DGTFVSGFFD KNSFKEYLAG WGKSVVVGRA RLGGIPFGAI 2280
AVETRTTEAR VPADPSSPDS RESVIMHAGQ VWFPDSAYKT AQAINDFNRG ENLPLIIFAN 2340
WRGFSGGTRD MFEEILKFGS QIVDALRTYK QPVFIYIPPH GELRGGSWVV VDPTINLQKM 2400
EMYADANARG GVLEPPGICE IKYRAADQKA LMHRVDDVLK ELDKQLQDCQ TASDAIDLKE 2460
KIKRREAALE PLYLSIARFY ADLHDRPERM KARGVISSIV NWKNSRTFFY WRAKRRLLQD 2520
DLEARILAAD ARLDYTKARA KIEDLLKSHG VDIAGDKAAC EFLSSTEGKE ATQAIVERSR 2580
REGAIEKIRD ILSSLPESER RETLESAATP AC 2612 
Gene Ontology
 GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004075; F:biotin carboxylase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro. 
Interpro
 IPR013537; AcCoA_COase_cen.
 IPR011761; ATP-grasp.
 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR001882; Biotin_BS.
 IPR011764; Biotin_carboxylation_dom.
 IPR005482; Biotin_COase_C.
 IPR000089; Biotin_lipoyl.
 IPR005481; CarbamoylP_synth_lsu_N.
 IPR000022; Carboxyl_trans.
 IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
 IPR011763; COA_CT_C.
 IPR011762; COA_CT_N.
 IPR016185; PreATP-grasp_dom.
 IPR011054; Rudment_hybrid_motif.
 IPR011053; Single_hybrid_motif. 
Pfam
 PF08326; ACC_central
 PF02785; Biotin_carb_C
 PF00364; Biotin_lipoyl
 PF01039; Carboxyl_trans
 PF00289; CPSase_L_chain
 PF02786; CPSase_L_D2 
SMART
 SM00878; Biotin_carb_C 
PROSITE
 PS50975; ATP_GRASP
 PS50979; BC
 PS00188; BIOTIN
 PS50968; BIOTINYL_LIPOYL
 PS50989; COA_CT_CTER
 PS50980; COA_CT_NTER
 PS00866; CPSASE_1
 PS00867; CPSASE_2 
PRINTS